We report here in four cases of gingival hyperplasia induced by Nifedipine and/or Cyclosporin-A.Patient 1, a 38-year-old male was given Nifedipine at 60 mg/day for about 4 months and subsequently developed gingival hyperplasia.Although, we performed oral hygiene procedures, the hyperplasia persisted, and the drug was replaced.Patient 2, a 23-year-old male, was given Cyclosporin-A at 250 mg/day and Nifedipine at 60 mg/day for about 1 year after renal transplantation.Patient 3, a 54-year-old male, received Cyclosporin-A at 500 mg/day for about 4 months after renal transplatation. We treated these patients using oral hygiene procedures.Patient 4, a 53-year-old female who had been given Nifedipine at 20 mg-40mg/day for about 7 years.In this patient, the lingual bar of the partial denture was buried deep beneath the hyperplastic gingiva, preventing her from removing it, and we performed gingivectomy after cleaning and scaling.
Histopathologic examination performed in patients 1, 2 and 4 revealed long and thin rate peg and, in the underlying connective tissue, a moderate number of fibroblasts and many interlacing bundles of collagen fibers were seen.These findings were similar to that described for phenytoin-induced gingival hyperplasia.Electron microscopy revealed fibroblasts with increased N/C ratio, collagen fibers secretion, and numerous secretory granules.
抄録全体を表示