In general, the efficacy of any medical treatment will be evaluated from the observation of the time course of symptoms which patients will present in response to the treatment.
After employing an appropriate model of an absorbing Markov chain, these time series data can be submitted to a statistical analysis.
In the model, a patient is represented as a stochastic system. Then the time process of the reactivity of the system to the treatment is examined in terms of its transition probability.
In the present paper, the validity of the method in studying the transitional pattern of the state of patient was investigated in the case of treatment of purpura.
The method with the model above mentioned proved to be of advantage in judging statistically the efficacy of the treatment.

抄録全体を表示

Graphene is a two-dimentional nanocarbon, which is stimulating great curiosity due to its superior mechanical, electrical, thermal and optical properties. Particularly attractive is the availability of bulk quantities of graphene which can be easily processed by chemical exfoliation, yielding graphene oxide (GO). In this study, poly(2-(N, N-dimethylamino) ethyl methacrylate) (PDMAEMA) chains have been grafted from the GO surface via atom transfer radical polymerization (ATRP), yielding a nanocomposite which can be formed polyioncomplex gel in polyanion (PAA) matrix. The GO and prepared film were characterized by FTIR, XRD, Raman, TGA, SEM and mechanical analysis. Moreover, the gel film can be converted from soft gel state into hard plasticization under ambient room temperature.

抄録全体を表示

岩盤の止水性評価はルジオン値の超過確率分布で行われてきた. ダム建設時に十分な止水性を確保するためにカーテンウォールを構築し, その止水性もルジオン値で評価している. 本研究では, ルジオン値の新しい分布形状のモデル化提案し, この分布形状からルジオン値の超過確率を求め, カーテンウォールの効果を評価している. 本手法を対象となった2地点に適用し, 有効な評価結果を得ている.

抄録全体を表示

各種胆道疾患274例についてこの薬効をデヒドロコール酸, プラシボを対照として二重盲検法により検定した.
4-Methylumbelliferoneおよびデヒドロコール酸は, プラシボに対し全般的に症状を改善した. 4-Methylumbelliferoneは, 右季肋部鈍痛, 心窩部痛, 食後痛, 右背部痛, 悪心, 便秘などの自覚症状, また圧痛, 抵抗などの他覚症状の改善に有効であり, とくに右季肋部鈍痛に対してはデヒドロコール酸より有効であつた. 4-Methylumbelliferone, は特記すべき副作用, また臨床検査成績の変化をきたさなかつた.

抄録全体を表示

Being interested in the broad-ranged individual variation of excretory 17-ketosteroids (17-kS) in urine on persons less than 10 years of age whose 17-KS are almost regarded as those derived from the adrenal cortex, I examined these daily excretions in urine of 22 normal and healthy children of aged from 6 years 9 months to 7 years 10 months (aver. 7 years 4 months) and, made a consideration about their individual variation.
1) measured 17-KS by the modified Holtorff-Koch's method with dehydro-iso-androsterone as standard.
2) The values of daily excretions in urines of these substances ranged from 1.4mg to 6.5mg (mean, 3.7mg: 3.2mg≤M≤4.2mg, α=0.05) in this age.
3) The extent of age of 14 months did not display a significant variation in these 22 cases.
4) The difference between boys and girls could also not be found.
5) I divided these children into two groups by the table of testing diathetic tendency used in our department. One group consists of those individuals whose bodies are more sensitive to various stimuli, and the other consists of those individuals whose bodies are not so sensitive, then I found significant lower values of 17-KS excretions in the former group.
According to the Sayers and Sayers' theory in which PERIPHERAL-HUMORAL-MECHANISM of homeostasis between ACTH and adrenocortical hormone plays a greater part in the PITUITARY ADRENAL SYSTEM, it could be said that individuals possessing fewer cortical hormones will deplete greater parts of these hormones and will induce larger proportions of ACTH from the pituitary under various kinds of stressful conditions, if surmised that the same quantities of cortical hormones in the tissue cells are utilized by the same quantities of stimuli. In other words, those individuals will produce the alarm reactions (Selye) more easily and more severely.
It may be of interest that individual variation of adrenal cortical hormones in bodies would indicate the degree of individual response to stimuli.

抄録全体を表示

多因子での直交計画にもとづく,観測時点をk,標本の大きさをNとする観測値行列Y(N×k)についての多変量分散分析について述べる,第2節で,L₈とL₉の例をあげて,そのわりつけと平方和・相乗和の分解を示し,経時変化の仮説と検定方式を示した,第3節では一般的な直交計画についての観測値行列Yの構造と直交変換をのべ,Yと同値なZ=P'Yによって,仮説検定を構成すればよいことを示した,第4節でL₆₄によって計画された実施例についてのべる.

抄録全体を表示