On investigating the uropepsin (U. P.) content of varying disorder, especially, gastric disorders, U. P. values were found to have a diagnostic value on gastric cancer and at the same time to give some valuable information for the treatment of various disorders, especially, gastric disorders.
1. U. P. values of cancerous disorders were mostly low, while those of ulcers were high with broader distribution. Patients of gastritis sometimes showed low values with fairly broad distribution. Patients of appendicitis were divided into two group of low and high U. P. values. Mild cases of pulmonary tuberculosis, moreover, were found to have broad distribution. Accordingly, U. P. values were found to be valuable not as a measure for differential diagnosis but as that of knowing the clinical status of individual patient.
2. In the patients of gastric disorders, gastric pepsin (G. P.) changes in parallel to U. P. in most cases, but in some cases it does not, which might probably due to the influence of adrenal functions and such cases were the patients of gastric cancer or ulecr.
3. Gastric acidity has a lesser degree of parellel relationship to the U. P. content than it does to G. P. Most cases showing nearly no pararellism.
4. Those who showed abnormality in Thorn Test possessed low U. P. values and those without any parallelism between G. P, and U. P. were found to have some disorders of the adrenal functions. Thorn Test abnormal cases were predominant among the patients of gastric cancer.
5 In contrast to appendectomy, U. P. values after gastrectomy show larger increase for longer period. No specific tendency was recognized, however, on the appearance of the peak of this increese. Patients of cancerous disorders showed small deviation in U. P. values.

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Investigations were made on the influence of several drugs on uropepsin (U. P.) as well as on the relationship between urodiastase and U. P.
1. Imidalin : Influence of Imidalin injection was investigated by the changes produced in the gastric acidity and U. P. content. U. P. showed an increase when the acidity at the time of hunger was above 20 even though the maximum acidity by the injection of Imidalin was above 31-61. While all the others, showed a decreasing tendency instead.
2. Adrenochrom, c preparation: U. P. content decreased by the administration of adrenochromic preparation temporarily but increased thereafter.
3. E, nzynolum: U. P, showed a moderate increase 2 days after administration of Enzynolum.
4. Urodiastase and U. P.: Both Urodiastase and U. P. showed a tendency to increase after operationn though there existed no parallelism between them.

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Report I. The sense of taste in normal individuals and in patients. And the relationship between taste and tongue coat, favorite and appetite.
Studies on the change of taste were done in normal individuals and in patients and further the relationship between taste and tongue coat, favorite and appetite were observed.
Result:
1. The threshold of sweet taste, sour, salty and bitter taste elevated in patients, as compared with the normal individuals.
2. In patients with tongue coat the threshold of taste is definitely elevated. Most striking elevation was sweet taste which was 0.49%, second was salty taste (0.19%) and then sour taste (0.035%). Bitter taste did not show any significant difference.
3. In patients with particular favorite of these taste except bitter, the threshold of favoue taste elevated contrary to elevated threshold of sour taste in patients without appetite.
Report II. Change of the threshold of taste in various disease and in various condition
Threshold of taste in 101 patients in diferent condition were studied. The relationship between taste and gastric acid content, blood sugar, serum electrolytes and sodium glutamate were studied.
Reslut:
1. In all patients the threshold of taste generally elevated. In patients with gastric or duodenal ulcer, elevation of sour taste and lowering of bitter taste were observed. In patients with hepatitis or cholecystitis elevation of sweet taste and mild lowering of salty taste and marked lowering of bitter taste were observed. In patients with liver cirrhosis elevation of sweet and bitter taste were observed, in particular the latter was striking. In patients with uremia or nephritis marked elevation of sour taste, moderate lowering of sweet and bitter taste and in patients with diabetes marked elevation of sweet taste and lowering of bitter taste were observed.
2. In patients with low gastric acid secretion, elevation of sweet and bitter taste, in patients with high gastric acid secretion elevation of sour taste were observed.
3. No definite relation between taste and serum electrolytes was observed.
4. In patients with high blood sugar the positive correlation between blood sugar and sweet taste was observed.
5. In accordance with the recovery of the clinical condition the threshold of taste returned into the normal range.
6. The threshold of taste with scdium glutamate was 0.041+0.012%. Threshold of sweet and bitter taste elevated with glutamate administration but marked lowering of sour taste and no changes of salty taste was observed.

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For the past ten years beginning with 1948 we have been using the intramascular injection of bismuth subsalicylate in treatment of 336 cases suffering from gastric and duodenal ulcers. From our experiences we believe that it is most appropriate to start with 0.5 cc of this drug for the initial injection and watching the reaction of patient carefully, to increase the dose by degree until the dose of 1.0 cc is reached. The over-all average time required and the average total dosage used for the entire group were 51.3 days and 6.16 cc respectively. However, looking over the different cases separately, the ones that showed the quickest response to the injection were the cases with duodenal ulcers in that it required on the average 36 days to recover completely and the average dosage of 4.45 cc per person; followed by the cases with ulcers of pars pylorica ventriculi and with ulcers of lesser curvature of stomach in the order mentioned. Moreover, no significant side-effects can be recognized in all the cases treated with this drug during the past ten years.

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