A study on obstructive changes in airways and mucociliary clearance in children and youth with bronchial asthma was performed. Radioaerosol inhalation lung scintigraphies using
99mTc-HSA (human serum albumin) were applied to 50 children and youth with bronchial asthma. The deposition patterns of the radioaerosol and aerosol clearance curves were evaluated.
Abnormal deposition patterns, which consisted of non-homogeneous distribution and/or hot-spot formation, were likely to be seen in cases with asthmatic attacks at the time of measurements. However, a few asymptomatic patients also revealed abnormal deposition patterns. The deposition patterns were related to FEV
1.0%, MMF, V
50 and V
25, but especially to FEV
1.0%.
As an index of mucociliary clearance, β, the rate constant of the
99mTc-HSA aerosol clearance curve, was introduced. β was significantly lower in cases with abnormal aerosol deposition patterns than in normal ones. β was also significantly lower in cases undergoing asthmatic attack at the time of the measurements than in asymptomatic cases. β correlated negatively with FEV
1.0%, MMF, V
50 and V
25, but especially with FEV
1.0%. Although cases with long term affection or moderate-to-severe asthma, tended to reveal abnormal deposition patterns and had low β values, these differences were not statistically significant.
Radioaerosol inhalation lung scintigraphy with
99mTc-HSA is useful for evaluating not only obstructive changes in the airways but also for evaluating mucociliary clearance in children with bronchial asthma.
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