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  • イヌにおける心拍変動とQTc
    小山 秀一, 良井 久, 馬場 朗子, 薮 秀之, 熊田 浩則, 福田 宏一, IP. U. HANG, 三谷 節生, 内野 富弥
    心電図
    1998年 18 巻 Suppl1 号 47-51
    発行日: 1998/03/25
    公開日: 2010/09/09
    ジャーナル フリー
  • 中田 義禮, 小林 秀俊, 局 博一
    動物の循環器
    2006年 39 巻 1 号 26-33
    発行日: 2006年
    公開日: 2006/11/01
    ジャーナル フリー
    医薬品安全性試験で心電図QT間隔の評価がこの十数年話題となってきた。 これは,QT間隔の延長とそれに伴うTorsade de pointesと呼ばれる多形性心室頻拍の副作用がみられた薬剤が市場から撤退したことによる。それゆえに医薬品安全性試験でQT間隔の評価は非常に重要である。ヒトやイヌ,サルの心電図においてQT間隔とRR間隔は正の相関で変化し,かつ非線形である。本報告では,サル長時間心電図におけるQT間隔のようにノンパラメトリックなデータの統計学的手法としてbootstrap法での分析方法を紹介する。
  • 福島 隆治, 市川 和世, 平林 美紀, 良井 朗子, 良井 久, 小林 秀俊, 松崎 智彦, 矢田 治郎, 小山 秀一, 廣瀬 昶, 内野 富弥
    動物の循環器
    2002年 35 巻 1 号 32-40
    発行日: 2002年
    公開日: 2005/06/28
    ジャーナル フリー
    The purpose of this study was establishment of conditions to measure blood pressure by a oscillometric method in dogs. For this study, 27 dogs and noninvasive blood pressure taking instrument for animal (BP100D) were used. This study got the following results. There were not significant differences between each blood pressure value measured in a foreleg, a hind leg and a tail. However, as for the time before measured value of blood pressure fell, and being stable, the measurement with a tail was shortest in about 5 minutes. The hair of measurement region did not influence a value of blood pressure. The value of blood pressure in the same animal was not influenced in circadian rhythm by heart rate and rhythm. As for the value of blood pressure in the same animal, it was not influenced by environment of the measurement. However, as for the time before measured value of blood pressure fell, the measurement in an accustomed kennel was shortest in about 5 minutes. These results suggest that the oscillometric method is suitable for measurement of blood pressure in dogs using a tail in the environment where dogs can be relaxed, and we can use values of blood pressure after five minutes from start of the measurement.
  • ―国際関係理論再考―
    大山 貴稔
    国際政治
    2015年 2015 巻 180 号 180_1-180_16
    発行日: 2015/03/30
    公開日: 2016/05/12
    ジャーナル フリー
    “International contribution”, diffused in the wake of Gulf War, is a peculiar idea in Japan. Western International Relations Theory (IRT) talks about “international coordination” and/or “international cooperation”, but never deals with “international contribution”. I’m going to focus on the idea of “international contribution”, which enables me to discuss Japanese perception of international relations and encourages me to reconsider so-called IRT.
    How does the idea of “international contribution” rise up to the surface? The historical overview of this question is presented in the first section. Through the rapid economic growth, the prime ministers of Japan such as Eisaku Sato, Yasuhiro Nakasone and Noboru Takeshita came to feel the enhanced international status as one of big powers, which was unaccompanied by Japan’s actual performance. This gap between the expectation from “international society” and the reality in “international society” provided the setting for the idea of “international contribution”. The emergence of this idea was nothing more than contingent use initially. Notwithstanding this genesis, “international contribution” precisely captured something like the flavor of the time and got into circulation.
    Then, how was “international contribution” mentioned? The structural outline, which is visible in the use of “international contribution”, is inductively extracted in the second section. The perception that Japan had taken “free ride” on “public goods” arousing international criticism keenly made Japanese realize the necessity of “international contribution”. Furthermore, “international society” is hypostatized in the background of “international contribution”, dredged through the comparison with “international coordination” and “international cooperation”. These understanding denote that at least for most of the Japanese the realm of international relations is not “anarchy”.
    Besides, how was “international contribution” as practice put into? Alongside of this question, transition of subject positions, especially pertaining to the Self Defense Force (SDF) and the Non-Governmental Organization (NGO), is reviewed in the third section. Although dispatching SDF which evokes the shade of military forces had long been regarded as taboo in the postwar period, the SDF brought about recognition as an actor of “international contribution” together with growing necessity of “international contribution”. NGO, on the other hand, came to accumulate fund and human material due to escalating interest in “international contribution”. Then the governmental awareness of NGO has gradually changed and the government has got to utilize NGOs.
    Various aspects of “international contribution” are sketched through the analysis of these chapters. Based on these aspects, I wonder if “international contribution” is a certain type of IRT. It functioned historically as a “lens” which gave us some “answers” at that time. If that’s the case, we ought to consider what the “academic” theory is and what it should be.
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