詳細検索結果
以下の条件での結果を表示する:
全文: "金属ヒューム熱"
3件中 1-3の結果を表示しています
  • 松下 行伸
    溶接学会誌
    2018年 87 巻 6 号 427-429
    発行日: 2018年
    公開日: 2018/09/12
    ジャーナル 認証あり
  • 平野 靖史郎
    日本衛生学雑誌
    1996年 50 巻 6 号 1013-1025
    発行日: 1996/02/15
    公開日: 2009/04/21
    ジャーナル フリー
    The present report describes toxicological approaches to evaluate inflam- matory potency of heavy metal compounds deposited in the lung. Although inhalation exposure is a well-accepted method to study effects of pulmonary toxicants, it requires expensive facilities and many man-hours to complete experiments. Intratracheal (i.t.) instillation, an alternative and simple method to expose animals to toxicants via airways, has been proved to be useful to investigate the pulmonary clearance of heavy metals. However, acute inhalation exposure caused more severe inflammatory lung injury than i. t. instillation when the same amount of nickel sulfate was administered in the rat. Among several biochemical inflammatory indices such as some enzyme activities and the protein concentration in bronchoalveolar lavage (BAL) fluid, only lactate dehydrogenase (LDH) activity increased linearly with a wide range of doses of heavy metals. The increase in polymorphonuclear leukocytes (PMN) in BAL fluid, a cytological index of inflammatory responses of the lung, is believed to reflect pulmonary toxicity of heavy metals. However, more extensive study is required to elucidate the mechanism of transpulmonary PMN infiltration upon heavy metal insult. In addition to the linearity between LDH activity in BAL fluid and doses of heavy metals, the increase in this cytosolic enzyme activity is associated with cell lysis in the bronchoalveolar milieu and appears to be the best index to evaluate pulmonary inflammatory potency of heavy metals.
  • 平野 靖史郎, 鈴木 和夫
    衛生化学
    1989年 35 巻 4 号 241-260
    発行日: 1989/08/31
    公開日: 2008/05/30
    ジャーナル フリー
    Recent studies on pulmonary clearance and toxicity of heavy metals (Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Cd, Hg and Pb) and Al (light metal) are reviewed together with comparative pulmonary toxicity among these metals. Metabolism and effects of Cd, Cr and Ni deposited in the lung have been relatively well investigated because these three elements are considered to have carcinogenic potency, but toxicological studies seem to be insufficient for the other elements. Solubility of metal compounds in the bronchoalveolar milieu depends on physical and chemical form (salts, oxide, sulfide, etc.) and may play a major role in pulmonary clearance rate, acute toxicity and carcinogenecity. Therefore, attention should be paid to the species of elements present in the environmental and work place atmosphere. The current Threshold Limit Values (TLV) for gallium, aluminium and zinc oxides might not be adequate and should be thoroughly reexamined. Toxicological priorities relevant to the work environment are discussed.
feedback
Top