Based on the levels of transfer capability of 405 physically disabled subjects the factors preventing them from going out of the house were analyzed. It was found that even in the group with the highest frequency of going out more than 60% felt a sort of hesitation when doing so. The mean reasons were transfer impediments, physical body factors, and anxiety and fear. The analysis showed that anxiety and fear were experienced especially at pedestrian crossings and/or crowded places. And we confirmed that the rate of remodel house for going out was lower than that for locomotion in the house.

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Virulence to mice and guinea-pigs of tubercle bacilli newly isolated from 43 Japanese tuberculous patients was reported previously. Virulence of these strains was not identical each other: many strains showed high or moderate virulence to mice and guinea-pigs, but some strains showed low virulence. To confirm the results of the previous experiments, and to observe the difference of tuberculous changes induced by heat-killed tubercle bacilli with different degrees of virulence, the following experiments were performed. In addition, the method evaluating the murine tuberculous changes with specific lung weight was discussed in this paper.

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It is generally known that the bending resistance of composite film, which consists of organic composition and filler, decreases as the amount and particle size of added filler increases. However, the precise relation between bending resistance(cycles at break in bending test : Bc)and filler has not been clearly known. For this reason, we examined the influence of filler on the Bc of composite film. As a result, we found that there was a linear relationship between the Bc and the specific surface area unit weight of filler in composite film(Sunit).Furthermore, the Bc value of unknown composite film(X)is able to be obtained from the breaking elongation of bulk film(X without filler)and Sunit of X from the linear relationship of the prediction relation. Finally, we verified the usefulness of the prediction relation with the composite film of different organic composition.

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Virulence to mice and guinea-pigs of newly isolated 43 strains of tubercle bacilli from Japanese tuberculous patients was reported previously. Many strains of tubercle bacilli showed high or moderate virulence to mice and guinea-pigs, but some strains showed low virulence to both animals. Two strains out of them were used for this study. One strain, No.105 had high virulence and the other, No.37 had moderate virulence to both animals.

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The virulence to mice and guinea-pigs of 43 strains of tubercle bacilli isolated from Japanese tuberculous patients were reported in the previous papers. Ten strains out of 43. were highly virulent to mice as well as to guinea-pigs (Group A). Three strains were moderately virulent to mice and highly virulent to guinea-pigs (Group B). Twelve strains had moderate virulence to both animals (Group C). Three strains were moderate to miceand low to guinea-pigs (Group D). Five strains had low virulence to mice and moderate virulence to guinea-pigs (Group E). And, ten strains of bacilli showed low virulence to both animals (Group F).

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The virulence of tubercle bacilli isolated from Japanese tuberculous patients to mice was reported in the 1st report, and the virulence to guinea-pigs in the 2 nd report. Comparison between the results obtained in mice experiments and in guinea-pigs experiments was carried out in this paper.

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1999年7月, 精神病院の入院患者である60歳代の女性が肺結核 (喀痰塗抹陰性, 培養陰性) として保健所へ届出された。この患者を発端として, 2001年3月までのおよそ2年間に, 入院患者等8名, 職員2名の計10名の肺結核患者が届出された。これらの結核患者のうち, 培養陽性となった3名の菌株についてRFLP検査を実施したところ, すべて同一系統の菌株であることが判明した。このことから, 結核院内集団感染と考えられた。定期外健康診断では感染源と考えられる患者は発見されなかったが, 退院患者等を検討したところ死亡退院患者で肺結核の可能性のあった者が1名浮かび上がった。この患者は死亡直前の胸部CT検査で空洞を認め, 喀痰PCR検査で結核菌群陽性であったが, 保健所への届出もなく, 放置されていた。また, この患者は発生した結核患者のほとんどの者と長期の接触があることが判明した。このことから, この患者が集団感染の感染源であると推定された。精神病院等の患者が長期療養する施設では, 定期的な胸部X線検査や呼吸器症状を有する患者への抗酸菌検査など, 適切な結核対策が必要であると考えられた。

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Experimental studies on the virulence of 43 strains of tubercle bacilli, isolated from the tuberculous patients who were newly discovered by the Tuberculosis Prevalence Survey in Japan in 1963 and 1964 and received no therapy, revealed that these 43 strains showed various degrees of virulence, from high to relatively low, in mice and guinea pigs. (KEKKAKU, 41, 359 and 427, 1966).

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