Investigations on rats with an implanted tumour-carcinosarcoma of Walker (26 animals), cancer of the mammary glands, RMK-1 (75 animals) and in mice with spontaneous cancer of the mammary gland (188 animals)-have shown that the application of a low-level diode laser beam (890 nm) can effect the growth of the experimental tumour. Minimal doses produce a tumouro-static effect, while other doses produce different effects. Low level laser irradiation promotes dystrophic and necrotic changes in tumoural nodes.

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The development of methods for the construction of foundations for buildings and structures using bored-injection piles allows expanding the scope of their application in seismic areas, as well as in complex and especially complex engineering-geological conditions. In this article, bored-injection piles are understood as piles formed in boreholes by injecting fine-grained concrete mixture under pressure through a hollow rod with a perforated drill bit at the end. The disadvantage of such piles in sandy clay soils is the limited bearing capacity of their upper part for the action of horizontal seismic loads and limited crack resistance of the reinforced concrete body. This is explained by the absence of a spatial rigid reinforcement cage or continuous external reinforcement in the pile. The role of reinforcement in these bored-injection piles is performed by a small-diameter (up to 103 mm) hollow metal rod located in the center of the cross-section. In this case, the upper section of the pile does not work effectively in resisting the reinforced concrete section to horizontal seismic loads. The proposed bored-injection piles differ from the known ones in that a reinforcing element made of a hollow metal pipe with a diameter of 0.3-0.4 meters is made in their upper part. To connect the hollow metal pipe with the underlying small-diameter metal rod, a screw-on transition coupling with a diameter equal to the diameter of the hollow metal section to be connected above is used.

installation, the hollow pipe is filled with concrete, and reinforcement bars are placed inside to subsequently form rigid connections with the body of the grillage or foundation slab of the building. This reduces bending deformations of the pile and achieves the required load-bearing capacity both in terms of material and soil during earthquakes.

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The paper presents a comprehensive approach to slope stability analysis and geotechnical monitoring during the construction of a church complex in the vicinity of Moscow. The site is located on a slope with a varied geological profile and thick fill material. The comprehensive assessment of slope stability involved additional engineering surveys, stability analysis, and optimization of retaining wall design solutions. The geotechnical monitoring program included inclinometer measurements and geodetic surveys. The results were compared with design values, and the data confirmed the effectiveness of the engineering solutions used for the complex geotechnical conditions. The article emphasizes the significance of a comprehensive approach to design and monitoring when constructing structures on slopes.

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The many stages of pathological, economic, sociological and psychological care and care-giving are described.

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Today, when developing territorial planning schemes for the subjects of the Russian Federation, as well as individual municipalities, it is necessary to identify territories at risk of rapidly developing natural hazards and man-made processes. This requirement is mandatory and reflected in the relevant regulatory documents. To achieve this, using modern algorithms for processing available information, including machine learning and artificial intelligence methods, a modern geoinformation engineering and construction model of planning restrictions for territories at risk of natural hazards is being created. This model allows approach the scenario of the hazardous processes development with a probabilistic risk assessment, achieving high forecasting accuracy for most types of geological processes. This model саn also be used as a basis for the development of methods for calculating and constructing effective foundations of buildings and structures located within such territories, and their practical implementation in built-up areas subject to the simultaneous influence of several factors of hazardous processes.

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The methods of rapid information processing aimed to reduce the time of realization of cryptographic RSA transformations are propounded in the paper. These methods are based on application of the principle of ring shift (PRS) in the module number system (MNS). MNS application, from point of view of increasing the speed of realization of cryptographic transformations with the open key, proves to be effective in organizing the process of realization of module integer arithmetic operations.

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Most intensive land degradation processes in Kazakhstan have been developed on rangelands. Although land degradation of rangelands is partly associated with sandy soils and dry climate in deserts, poor rangeland management aggravated during the process of land privatization is a major factor. Land degradation of cropland in rainfed agriculture occurs mostly through soil erosion by both wind and water. Although wind erosion is prominent, much land degradation has been caused by erosion by water as well. Research has shown that one of the major means of addressing the issues of soil erosion on cropland in rainfed agriculture is the elimination of the summer fallow practice on black soils and the adoption of chemical summer fallow concept in dry steppe regions. In the last three years, the area under summer fallow was reduced by 1 million ha. The other measure is No-Till and minimum tillage, which are currently adopted practices on 11.2 million ha of cropland. Degradation of cropland in irrigated agriculture occurs even more intensively because of poor management of soil drainage and irrigation systems. Saline seepage in particular is a major problem in these soils. Therefore, policies should be directed towards rebuilding of all irrigation and drainage constructions.

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放射線治療後晩期有害事象に対し，高気圧酸素療法が施行された29例を対象に，その治療効果などについて検討した．障害内容の内訳は，（上）下顎骨壊死あるいは骨髄炎 8 例，直腸粘膜障害 7 例，出血性膀胱炎 7 例，食道潰瘍 3 例，喉頭壊死 2 例，放射線脊髄症，皮膚潰瘍が各 1 例であった．高気圧酸素療法前後の状態をRTOG/EORTC遅発性放射線反応評価基準に従って評価し，gradeで 2 段階以上の減少を著効，1 段階の減少を改善とした．著効率は17％，著効，改善を合わせた奏効率は79％であった．治療による増悪例は認めず，重篤な副作用も見られなかった．文献的には単一の障害に関する高気圧酸素療法の経験の報告があり，奏効率も同程度の結果が多いようである．放射線治療後の晩期有害事象に対しては，ほかに有効な治療法が少ないため，治療の選択肢として認識し，積極的に適応してみるべきであると考えた．

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The essential technological distinctions of the Novovoronezh NPP-2 (NV NPP-2), equipped with passive safety systems, determine some specifics in the character of accidents with the coolant leaks from the reactor primary circuit and the refusal of active part of the emergency core cooling system (ECCS). In the case of an accident with depressurization of the reactor primary circuit, the system of passive heat removal (PHRS) ensures the transition of steam generators (SG) into the mode of steam condensation. As a result, a condensate comes to the core, providing its additional cooling. Upon the steam generators operation in condensation mode, the significant influence exerts the presence of non-condensable gases in the primary circuit. The accumulation of the non-condensable gases in the steam generator pipelines results in the deterioration of its condensation ability. The design decisions considered in the project enable the removal of non-condensable gases in the composition of gas-steam mixture coming from the SG into the hydroaccumulators of second stage system (HA-2) to be guaranteed. For the experimental verifying of the sufficiency of such mixture outflow from SG into the HA-2 system to maintain the SG condensation power, the large-scale test facility HA2M-SG was constructed in IPPE. The experiments dealing with the study of condensation mode of SG operation under the ingress of mixture of steam with non-condensable gases into pipelines and synchronous outflow of gas-steam mixture were carried out at the test facility. The experiments were carried out by the method of steady states at the steam pressures of 0.35-0.36 MPa.

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It is reported that the WN gear has higher load capacity. Windhaven included the idea of the arc teeth perpendicular to the teeth trace in his patent application of WN gear. Maki has proven the validity of the principle of arc teeth perpendicular to the teeth trace by means of vector analysis. This study is related to the design, processing and measurement of the WN helical gear and spiral bevel gear with arc teeth perpendicular to the teeth trace.

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Background Arrhythmia is a major late complication in adults with repaired tetralogy of Fallot, although a large-scale study has not been carried out in Japan. Methods and Results A nationwide multicenter study with 512 operative survivors was performed. Actuarial survival rate at 30 years (maximum follow-up) was 98.4%. Fifty-four patients (10.5%) had clinically important arrhythmias, including 23 patients with bradycardia caused by sick sinus syndrome or atrioventricular block (AVB). A patient with complete AVB (CAVB) without pacemaker implantation (PMI) died later. Two patients had sustained ventricular tachycardia (VT) and syncope was reported in 18 patients with ventricular arrhythmias (VA). Atrial tachyarrhythmias were observed in 13 patients. Older age at operation was a risk factor for atrial fibrillation/flutter, longer postoperative survival duration for VA, and QRS duration >120 ms for VT. Perimembranous ventricular septal defect was related to CAVB. Right ventricular outflow patch was not a risk factor. Importantly, 60% of the subjects had QRS duration <120 ms. Conclusion The prevalence of serious arrhythmias is low in Japanese TOF patients as compared with the results from Western countries. CAVB without PMI and VT are the major risk factors for late morbidity and mortality. The excellent result could be related to the narrow QRS surgery. (Circ J 2004; 68: 126 - 130)

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Induction of prophage λ in ultraviolet light sensitive ruv mutants of Escherichia coli K-12 was studied. When the ruv⁺ thy (λ) strain was starved for thymine, a maximum induction occurred about 150min, whereas induction of the ruv thy(λ) strains reached the same level at about 90min. The number of infective centers in a ruv⁺tif (λ) strain reached a maximum at 60min the temperature was raised to 42°C, whereas a maximum induction was achieved at 45min in the ruv tif (λ) strains. These results suggest that the ruv mutations affect the process of prophage induction in thy auxotrophs and in tif strains.

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Nowadays, due to the increase in the number of storeys of structures under construction, the number of buildings erected on pile foundations has increased. A large number of theoretical and experimental studies of pile operation under load have allowed the development of various methods for calculating pile settlement. However, most of them do not take into account the technology of pile construction, which affects the change in the properties of the contact zone soils. In addition, most of the methods assume that the settlement of the pile is equal to the settlement of the soil, but in reality,

reaching the ultimate strength, the pile has the possibility of slipping through the soil. The main purpose of this paper is to investigate the influence of the interface friction coefficient (strength reduction factor Rinter) on the results of pile settlement calculations performed by numerical method in the geotechnical software package Plaxis. In this paper, the interface friction coefficient was determined from the results of laboratory shear tests of sandy and clayey soils over concrete, in accordance with the current regulatory documentation (SP 22.133330.2016 «Soil bases of buildings and structures») and back calculation based on field tests. Based on the results of the calculations, graphs of load-dependent settlement were plotted and a comparative analysis of the results obtained with the results of known field tests of bored piles by static loading was performed. Based on the comparative analysis, conclusions were drawn about the influence of the method of determining the interface friction coefficient on the pile settlement calculation results, the influence of the pile construction technology on the interface friction coefficient value and recommendations on how to take this coefficient into account in the calculations.

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