The pathogenesis of fluctuating sensory-neural hearing loss was classified into two types. In the first type, both hair cells and nerve cells are normal and the auxiliary tissues of the inner ear only are reversibly involved. By contrast, in the second type, hair cells and/or nerve cells themseles are involved by reversible degeneration but the auxiliary tissues are normal. In the former, especially the stria vascularis was thought to play an important role.
Cochlear potentials, Preyer's reflex and post-rotatory nystagmus in guinea pigs were recorded under application of anoxia and intravenous administration of furosemide. The 8th nerve action potential of the Ménière's disease was also examined and analysed by means of an anlog averaging computor.
These experimental results induced the conclusion that vascular or metabolic insufficiency of the stria vascularis caused a reversible hearing threshold elavation of 30-35dB for all frequencies, and then change of ion composition and volume of endolymph resulted in a reversible inner ear conductive deafness.
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