[1] The purpose of this reserch is to make clear what type of design can give good effects to win the high readership score. At the begining I had to know what factors decide the readership score, and how to change the quality of the desing into numerical value. I have used the method of multi-dimentional analysis with the help of a computer, and got the estimation formula, with kinds of factors, as follows ; A^^〜=+C+D+K+++cG. A^^〜=estimated values of the readership score. 1) , C, D, K : these four factors are given as category values (so we call them); each factor is classified into several categories. =week day, classified into categories. C=pages of a newspaper, which are characterized by the kinds of articles, news, and the other reading matters, classified into categories. D=kinds of goods and trades of the advertizement, classified into 14 catedories. K=constants, given to each 13 surveys. 2) , , G : these factors are given as numerical values. G=area of advertizement, measured by the unit of column in the whole page length, being classified into kinds of area (2., ., , , 10, 15) and 15 column means a whole page, about 2,000cm^2. , are the marks obtained in the design of advertizements. =sum of the marks obtained in each design element on the advertizement. =the marks obtained on the whole effect of the design. ) a, , c : coefficients Using the above formula with the category values and the coefficients, we can obtain the naked design effect from the actual value A of readership score: +=A-(+C+D+K+cG). In this research, I used 1,829 data of readership score from 1960 to 1968, being obtained by 13 survevs, spring and autumn twice a year. The sample of size each survey was ,541, 2,251, or 200 in the other 11 surveys. Multiple correlation coefficient between the estimated value A^^〜 and the actual value A is 0.951. The table 2^* shows the contribution indexes of each factor by kinds of expression-(1) Range : the absolute difference between the maximum and the minimum category values, (2) Standard deviations of the category values, () Partial correlation coefficient : the relationship between the actual values A and each factors. *see the table 2 in the thesis in Japanese. [2] The important point was in the determination of the values of , . is the sum of the marks obtained in each design element, classified into four kinds : =_1+_2+_+_. design elements [table] _1, _2, _, _, these values have the grades, as 0, 1, 2, , and 0 is given to the design that has no attractive effect or no applicable element. And obtain the marks of 0 to 9 grades as the sum of them. The values of have also grades, 0 to . The principles to determine the values of , are as follows : a) The marks obtained of , must be the relative values among the each survey, and at the same time, they must have constancy within the same survey-the same elements of design must win the same marks obtained. ) They must be determined as to win the highest multiple correlation coefficient, when they are put into the estimation formula. c) They must be reasonable. In order to justify them, we must carry many researches on the actual condition. The frequency of accurence of each grade of , values, as the table -, and - in the thesis in Japanese.

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This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant

. coli isolates were detected in (.2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: bla_CTX-M-15 (62), blaTEM-

1b

(42), bla_CMY-2 (

22

), blaCTX-M-

3

(16), bla_CTX-M-1 (15), bla_OXA-1 (9) and bla_SHV-12 (

3

) alone or in combination. The most frequently encountered phylogenetic group was group A₁ (35.

8

%), followed by group D₂ (

22

.1%),

B

1 (15.

8

%), D₁ (9.

5

%), A₀ (

7

.

4

%),

B2₂

(

5

.

3

%) and

B2₃

(

4

.2%), respectively. PMQR genes, aac(

6

’)-Ib-cr, qnrS1 and qnrB10 were detected in 25.

3

, 10.

5

and 1.1% of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.0% for tobramycin to 56.

8

% for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE,

f17a

-A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing

E

. coli clone O25

b

:ST131/

B

2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing

E

. coli isolates among dogs in Turkey.

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The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.

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The ability of Climacodon septentrionalis to immobilize and kill a mycophagous nematode (Aphelenchoides sp.) in vitro is described for the first time. Two isolates produced droplets (20–45 μm in diameter) that formed at the apices of tall, stalked, and branching secretory cells (700–1,500 μm tall). On 2% modified malt extract agar, nematodes became enveloped in the droplets, which restricted their ability to move and resulted in complete immobilization and death within several hours of contact. The rate of decomposition of the nematodes varied considerably, with most individuals persisting for weeks whereas others were degraded within several days and appeared to be colonized by dense hyphal growth. This study provides the first documentation of a non-agaricoid fungus producing secretory cells that are able to immobilize nematodes.

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A sample of [

3H

] tobrarnycin (

5

, 000 Ci/Mole) has been synthetized and incubated with
the bacterial ribosome and its subunits. The results obtained show that this antibiotic has
two types of binding sites. The primary one is probably responsible for the inhibition of
protein synthesis whereas the secondary one is probably related to the misreading and reading
tiirough of the messenger RNA.

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The phase diagrams of the Ni-Mo- and Ni-W- ternary systems in the region of less than 50mol% were constructed by thermodynamic calculation, based on the data obtained by thermodynamic measurement of the related materials. We found three ternary eutectic points and three or two ternary peritecto-eutectic points as follows:
:L (1365K, 71.mol%Ni-.0mol%Mo-.mol%)=(Ni)++
:L (1355K, 62.mol%Ni-2.mol%Mo-30.mol%)=++
:L (1445K, 42.0mol%Ni-30.mol%Mo-10.mol%)=(Ni)+NiMo+
P₁:L (1812K, 34.9mol%Ni-42.mol%Mo-.mol%)+MoB=+
P₂:L (1633K, 42.mol%Ni-40.mol%Mo-17.mol%)+Mo=+
:L (1812K, 53.mol%Ni-33.mol%Mo-12.mol%)+Mo=NiMo+
:L (1622K, 51.0mol%Ni-31.mol%W-17.mol%)=(Ni)+W+
:L (1260K, 71.0mol%Ni-.0mol%W-.0mol%)=(Ni)++
:L (1291K, 65.mol%Ni-.mol%W-29.mol%)=++
P₁:L (2115K, 23.mol%Ni-43.1mol%W-33.1mol%)+WB=+
P₂:L (1657K, 48.9mol%Ni-33.1mol%W-18.0mol%)+=W+
The calculated phase diagrams are expected to be useful for the development of new Ni-based heat-, corrosion- or wear-resistance alloys.

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The synthesis of metal ion adsorbents from modified banana fibers comprising a Schiff base was investigated. The adsorption properties of a metal ion adsorbent were evaluated, and banana fiber (

)-g-(glycidyl methacrylate)(GMA)(-GMA) were synthesized. A Schiff base 2,2’-{iminobis[ethane-2,1-diylnitrilo()methylidine]}bisphenol was synthesized via a reaction of diethylenetriamine and -bromo-salicyialdehyde in methanol. A metal ion adsorbent (-GMA(Br)) was synthesized via a reaction of the Schiff base with -GMA. Over 90% of +, +, +, +, +, +, +, +, +, +, +, +, and + were adsorbed in a pH range of .0–. by the synthesized metal ion adsorbent. Almost 100% of + at a pH value of .0–.0 and % of + at a pH value of .9 were absorbed, thereby showing the maximum adsorption percentage. Almost 15% and 25% of + was adsorbed at a pH value of 1.–1. and 1., respectively. Adsorption of + was barely observed in the pH range of 1.–1.. These results show that banana fibers can be utilized as metal ion adsorbents.

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(-)-Talaumidin (1), a 2,-biaryl-,-dimethyltetrahydrofuran lignan, isolated from the Brazilian Aristolochia arcuata Masters, showed significant neurite outgrowth promoting and neuroprotective activities in the primary cultured rat cortical neurons and NGF-mediated PC12 cells. Talaumidin (1) possesses the four continuous stereogenic centers on a tetrahydrrofuran ring, therefore, there are the possible seven diastereoisomers for 1. From a synthetic point of view, it is attractive not only to construct the four consecutive chiral centers stereoselectively, but also to prepare a stereoisomer library that would provide useful information on the structure-activity relationship of 1. In this symposium, we report the systematic synthesis of all stereoisomers of (-)-talaumidin and their activity. The stereoisomers 1a, 1 and 1c were synthesized from the common intermediate , which was prepared by and anti-Evans aldol reaction of 2 with . 2S,S,S,R-1a was derived from dihydrofuran 11 by the stereoselective dehydrogenation. Reduction of hemi-acetal 12 with NaBH_CN in the presence of _・OEt_2 gave rise to 2S,S,R,S-1. Furthermore, the diol 13 was subjected to the MItsunobu reaction, resulting in the formation of the single isomer 2S,S,R,R-1c. On the other hand, syntheses of 1d-1g bearing a (2S,R)-configuration was accomplished by using the syn-selective Evans aldol reaction as the first step. 2S,R,S,S-1d were synthesized by the Mitsunobu reaction of diol 25 using Tsunoda reagent, CMMP, and also 2S,R,S,R-1 was prepared by catalytic stereoselective reduction of dihydrofuran 21. Synthesis of 2S,R,R,S-1 was achieved according to Hong's procedure, which is Grignard reaction with ZnBr_2 toward sulfone acetal . Finally, treatment of 26 with _・OEt_2 led to the oxonium ion with epimerization at C-, which was subsequently reduced with NaBH_CN to give rise to 2S,R,R,R-1g. All of the prepared stereoisomers were evaluated for neurite-outgrowth of NGF-mediated PC12 cells. As results, all stereoisomers were found to whow moderate neurotrophic activity except for 1 at 30μM. In particular, 1 having all cis substituents exhibited most potent neurite-outgrowth promoting activity.

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The Gujarat earthquake in India occurred in January, 2001, and caused significant damage in the province of Gujarat. The Japanese Geotechnical Society sent a small reconnaissance team to the damaged region after the quake. The present text presents the report from this activity. The major attention of the team was focused on geotechnical aspects of the damage which were related to earthfill dams and harbor land fills. It was found that a significant portion of damage was concentrated in fills resting on soft natural soils. Swedish weight soundings which were conducted at two places demonstrated the existence of such a soft subsoil. From this, it was concluded that amplification of earthquake shaking as well as the permanent deformation in the soft foundation soil induced such kinds of damage as subsidence, cracking, and lateral spreading in overlying artificial fills. For the better seismic resistance of those affected fills during future earthquakes, the improvement of soft subsoil seems essential.

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The boundary element method expanded in frequency domains is presented to analyze the dynamic interaction between an embedded flexible rectangular foundation and soil with consideration of the obliquely incident waves. Numerical results describing the influence of the flexibility of the foundation on the dynamic responses of the foundation due to obliquely incident waves indicate that the flexibility of actual foundations can diminish the reduction of translation responses and increase the rotational responses in the high frequency range. These phenomena are more conspicuous as the embedment ratio is larger and the value of the wave velocity ratio of the soil and the foundation approaches to unity. When the high frequency components of the input ground motion are important and the basement has higher flexibility (for example ₂v_s/₁v_s >0.), the analysis method which considers the basement as a rigid foundation may lead to unsafety estimations and the estimation of the flexibility of the foundation is necessary as analysing the effective input motion with consideration of the incident waves.

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Six sorts of aluminium-silicon JIS commercial cast alloys, i.. AC2, AC2BT, ACAF, ACAF, ACAT and AC, were examined on drill-machinabilities in regard of drilling resistance, accuracy of drilled holes, deposits on the drill face, chip treatment and others. The results obtained were summarized as follows:
(1) In the case of -materials (as-cast), the drilling resistance and time were smaller in copper-containing materials, i.. 2 and , and were larger in AF, especially AF. And the drilling resistance and time of T-materials (heat-treated) were larger than those of -materials.
(2) The drilling temperature was lower in AT than in the other materials, but the temperatures were about 100∼120°C as a whole and posed no serious problem.
() In the case of -materials, the accuracies of drilled holes, i.. enlargement of the hole diameter, roundness of the hole figure and surface roughness of the drilled hole in AF and AF were inferior to those in 2 and , and the roundness of the hole figure and the surface roughness of holes in T-materials were better than those in -materials.
() In the case of -materials, the deposits, such as a cohesive large built-up edge, which deteriorate the accuracy of a drilled hole, were observed on the drill face. This phenomenon was more remarkable in AF, especially AF than in 2 and . And the deposits in T-materials were less cohesive and smaller than those in -materials.
() There were no difficulties in chip formation regardless of the chip treatment.

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As a fundamental study on dibenzothiepins, reaction of 11-phenyl-, 11-dihydrodibenzo [, ] thiepin-11-ol (10) or 11-chloro-11-phenyl-, 11-dihydrodibenzo [, ] thiepin (14) with triphenylmethyl cation or was examined under various conditions. 11-Phenyl-, 11-dihydrodibenzo [, ] thiepin-11-ylium salt () was isolated as a black powder (perchlorate) and a green powder (hexachloroantimonate), but salt was obtained only as a solution. Treatment of the hexachloroantimonate with excess of was found to result in a novel dehydrocyclization reaction to give selectively 9, 13-dihydrofluoreno [1, 9a, 9-c, d] [2]-benzothiepin-13-ylium hexachloroantimonate (19). Some discussions were made on the mechanism of the formation of 19.

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Two new partially saturated tricyclic ring systems, , a, , , 9, 10, 10a, 11-octahydro-11-oxodibenz [, ] oxepins (a and ), and -thiepins (a and ) were synthesized. Compounds a and were desulfurized to give a pair of isomeric 2-methylbenzoylcyclohexanes (10a and 10). Deuterated a and (11a and 11) were prepared starting from butadiene- (12). The stereochemical features of a (trans), (cis), a (trans) and (cis) are compared with those of 10a, 10, 11a and 11 on the basis of proton nuclear magnetic resonance data.

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