B
. subtilis spores,
E
. coli BB
-1 and
E
. coli B
/r were bombarded with α-particles and heavy ions of carbon, nitrogen and oxygen accelerated in the IPCR Cyclotron. The RBE versus LET
∞ curve for
B
. subtilis spores showed a maximum peak at ?? 120 keV/μm, while those for
E
. coli BB
-1, and
E
. coli B
/r declined without any maximum as LET
∞ values increased. In the region of α-particles, the effective inactivation cross section (S
eff) for these three strains increased with increasing LET
∞ and the rates of increase in S
eff in the LET region from ?? 30 to ?? 150 keV/μm were 15.0, 1.
5
and 2.
5
times for
B
. subtilis spores,
E
. coli BB
-1, and
E
. coli B
/r, respectively. In the case of
B
. subtilis spores, S
eff values for heavy ions were almost independent of their energies, but the other two strains showed a considerable dependence upon beam energy. The charcteristic LET dependence of S
eff observed in this study was fairly well explained by the target theory based on microdose concept.
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