All the birds examined were also associated with bone dysplasia (art alczaormal develop-ment of bone tissue) in the diaphyseal cortex of the leg bones, especially of bones affectedwith dyschondroplasia. This result is very significant in order to clarifyz tlais disease entity.1970:J14, k -1 } 7 ) 7, M77 ) i? ht /, ( K ) 7 ( # L", MB @ (7) t, If!TB& U ", Jff Dyschondroplasia (1*t%7fi!dW) ().g:#[!:.fLlt! K?3o, [1: (7)M;tC, rff.?U/:cD, =1lC#li*H(DX15RI!!D& t, r, ccl)Efff7flr.#.??t"ut:.?T<3.1.?l??/?t:>"A??1!? > >?TMOll?, lI]%G (-srRM) -ts;;.*BI) *M[t fL 54 t:.;*.{1*I[l?(), t@Yllll*fJ?H@(7) %?Jfipj@ (Dyschondroplasia) p, }, (, 1lTi{-X, WIKIM itt{= t D"tl%tff{tO 1111IH(-UP!z U-ii) >ES- -)%Wi*fd?1J*[lEj: >11"iifI".*"H*Tl*&Z") #)/?-"k l - vich ) J&it(Vh3iO"= >If-ffi"!1lYl*I4")Ji/l![40111!>D*!)<Y14M)?A"!>CL(Il], k7.ClT"ltTt*flB1? & $4U [-" U" L % w, Zl1*.IlBl tI1J, FA(y L-x") LVfAK t: >3llltPJ4IiI " } ) t- ! Al j: >kP11liR, &ffl(NWi Z 3lk(#L" Ct ?!4M"- fL#, -()%.IWMd1.XI1*I1EPW(tit ff1lR)

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A sample of [³H] tobrarnycin (, 000 Ci/Mole) has been synthetized and incubated with
the bacterial ribosome and its subunits. The results obtained show that this antibiotic has
two types of binding sites. The primary one is probably responsible for the inhibition of
protein synthesis whereas the secondary one is probably related to the misreading and reading
tiirough of the messenger RNA.

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Thirty-six patients (19 males, 17 females: atypical schizophrenia; 3, typical schizophrenia; , depression; 11, neurosis and other psychiatric disorders; ) were operated on according to orbitoventromedial undercutting by Hirose. In all cases, the Rorschach test was carried out and daily behaviors were studied. Thirty-one scales of the test were subjected to multivariate analysis whereas the behaviors were evaluated according to the following criteria, i.., A: recovered or symptom free, : markedly improved, : moderately improved, D: slightly improved and : not improved. The following results were obtained.
1) The evaluation of behaviors is as follows. A: 12 cases, : , : , D: , : none.
) It was found that scores of +106% and R+106% scales were significantly higher after the operation than before; that correlation coefficients between the scores before and after the operation were considerably high.
3) Factor analysis followed by varimax rotation was carried out. Six factors were extracted, i.., (1) sensitivity to emotional stimuli, () ego-strength, (3) obsessional rigidity, (4) reaction time, () anxiety and tension and () empathy. It was revealed that was high in atypical schizophrenia, depression and neurosis, and that and were significantly different in terms of the factor scores among the four groups A, , and D; was highest in A, and lowest in D regardless of whether it was before or after the operation. showed high scores in both A and , and low in D.
4) Multiple discriminant analysis was applied to the data of the Rorschach test before the operation, by classifying 36 subjects into the four groups A, , and D. As a result, high rates of correct diagnosis were obtained, i.., 100% for A, 78% for , 56% for and 100% for D. When the groups and D were combined into one group (+D) the highest percentage (100%) was seen in A, followed by (89%) and +D group (%). When the groups A and were combined into one group (A+), the percentages of correct diagnosis were 81% for A+, and 93% for +D.
In conclusion, it can be said that scales of the Rorschach test have been proved to be valid for predicting mental and physical states after the orbito-ventromedial undercutting.

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カンキツ主要12種を用いて染色体のクロモマイシン A₃(CMA) 染色を行った．染色体は CMA(+) バンドの有無および位置から 7 種類に区分できた．すなわち，CMA(+) を A: 両端および動原体近傍に有する，: 一方の端部と動原体近傍に有する，: 両端に有する，D: 一方の端部に有する，: CMA(+) がない，: 動原体近傍に有する，Dst: 付随染色体を有する D 型，である．各種はこれらのうち ～ 種類の染色体を有し，独自の CMA バンドパターンを示した．

C

. medica では + D + ，

C

. limon では 1 + 1 + D + ，

C

. aurantifolia では + D + 7，

C

. aurantium では 1A + 1 + 1 + 7D + ，

C

. sinensis では + + 7D + 7，

C

. maxima では 3A + 3 + 4D + ，

C

. paradisi では A + 3 + D + 7，

C

. ichangensis では + + 12D + ，

C

. latipes では A + + D + 3，

C

. micrantha では 1 + 11D + 4 + Dst，

C

. macroptera では + 1 + 11D + 3 + 1，

C

. hystrix では 3 + 1 + D + 3 + + 1Dst であった．

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Two new partially saturated tricyclic ring systems, , a, 7, , , 10, 10a, 11-octahydro-11-oxodibenz [, ] oxepins (3a and 3), and -thiepins (4a and 4) were synthesized. Compounds 4a and 4 were desulfurized to give a pair of isomeric -methylbenzoylcyclohexanes (10a and 10). Deuterated 4a and 4 (11a and 11) were prepared starting from butadiene- (12). The stereochemical features of 3a (trans), 3 (cis), 4a (trans) and 4 (cis) are compared with those of 10a, 10, 11a and 11 on the basis of proton nuclear magnetic resonance data.

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Low molecular weight glutenin subunits are important components of wheat storage proteins, which play an important role in determining end-use quality of common wheat. A newly established matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) procedure was used to analyze 478 landraces of bread wheat collected from the Yangtze-River region in China. Results indicated that 17 alleles at three loci: Glu-A3, Glu-

and Glu-D3 were identified, resulting in different allele combinations. Of the 17 alleles detected at all the Glu-3 loci, five belonged to Glu-A3, seven to Glu- and five to Glu-D3 locus. MALDI-TOF-MS indicated Glu-A3a/ was present in 72.%, Glu- in .4%, Glu-A3d in .4%, Glu- in .% and Glu- in 3.% lines. Seven types of alleles were identified at the Glu- locus: Glu-

B

3d/i (25.%), Glu- (21.3%), Glu- (16.%), Glu- (13.%), Glu- (.4%), Glu- (.%), and Glu- (.%). Five types of Glu-D3 alleles were detected: Glu-D3a (58.4%), Glu- (.%), Glu-D3d (15.%), Glu- (3.3%) and Glu- (.%). Four new alleles that showed abnormal MALDI-TOF spectrum patterns were identified at the Glu-A3 and Glu- loci. A detailed study is needed to further characterize these alleles and their potential usage for wheat improvement.

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11-Amino-, a, 7, , , 10, 10a, 11-octahydrodibebenzo[, ]thiepines (a-d) and -oxepines (7a-d) were synthesized by the Leuckart reaction of , a, 7, , , 10, 10a, 11-octahydro-11-oxodibenzo[, ]thiepines (1a, )and -oxepines (a, ) followed by hydrolysis of the reaction products 4a-d and a-d, respectively. The four diastereomers, cis(a-H, 10a-H)-cis(10a-H, 11-H) a and 7a, cis(a-H, 10a-H)-trans(10a-H, 11-H) and 7, trans(a-H, 10a-H)-trans(10a-H, 11a-H) and 7, and trans(a-H, 10a-H)-cis(10a-H, 11-H) d and 7d, were isolated and their configurations and conformations were elucidated by chemical methods together with ¹H-nuclear magnetic resonance spectroscopic and X-ray crystallographic analyses.

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The advantages and disadvantages of using a back analysis of slope failures to evaluate soil shear strength are discussed. A methodology is presented herein that allows the implied level of reliability associated with soil shear strength parameters back calculated from slope failures to be estimated. A reliability approach is also used to estimate the probability of failure for a given limit equilibrium slope stability method, design factor of safety, and combination of back calculated Mohr-Coulomb shear strength parameters, ' and φ'. The methodology is illustrated using 39 landslides in the Orinda Formation in the San Francisco Bay area. The impact of additional case histories in the same geologic setting, i.., a larger data set, on the required design factor of safety for a given probability of failure is also investigated.

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(³H) Tobramycin was used as a probe to determine the relationship between the structure of aminoglycoside antibiotics and their ability to remove this drug from its higher affinity binding site on the ribosome. The dissacharide moieties (neamine, tobramine, gentamine) appeared to have a common binding site, whereas the kanosamine, garosamine and ribose moieties determined the specificity of this binding. Amikacin and butikacin behaved in an anomalous manner in spite of their close structural relationship to tobramycin.

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The Beckmann rearrangement of aliphatic ketone oximes, R(CHs)=NOH (R=Et (1); n-Pr (); iso-Pr (3); iso-Bu (4)), with polyphosphoric acid (PPA), polyphosphate ester (PPE), and ester of phosphoric acid ( P- R) was carried out and migratory ratios ((a)/() in eq. (1)) were determined, The results are shown in Fig.1, , and 3, respectively.
In Fig.1 and , the migratory ratios decrease with reaction time and nearly approach to the ratios of anti-alkyl form/syn-alkylform in benzene(A1) or DMSO(A)except for (3) (See Table 1). From this fact, it has been found that PPA and PPE are inactive for isomerization of the oximes andanti-alkyl oximes rearrange faster than syn-alkyl ones. ln the case of (3), migratery ratios are smaller than Ai or A. As acetonitrile is detected by GLC, it is presumed that fission has been occurred simultaneously with rearrangement in anti-alkyl oxime (eq. (3)). In the case of P- R, all modes of the reaction arethe same as in above, except that the rate of fission is tnuch faster than that in PPA and PPE.
The reaction of anti-alkyl ketone oximes having a bulky grouphas been greatly influenced by the use of sterically demanding catalysts such asPPA, PPE, and P- R.

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The activities of tobramycin derivatives acetylated and ethylated on the '-N, '-N and 3-N positions were examined. The MICs of these derivatives against tobramycin sensitive strains indicated that '-N-ethylated and '-N-ethylated derivatives have a fairly good activity, and confirmed that the 3-N position is the most important one for antibiotic activity since 3-N derivatives were less active. The MICs of these derivatives against tobramycin resistant strains, and their inactivation by tobramycin modifying enzymes were examined. These results showed that '-N or '-N ethylation protects the drug against inactivation by AAC(') or AAC('), respectively, and '-N-ethyltobramycin and '-N-ethyltobramycin were active against strains containing these modifying enzymes. On the other hand, 3-N ethylation protects the drug against inactivation by AAC(3) but 3-N-ethyl tobramycin does not inhibit strains containing this enzyme.

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The modulns of longitudinal elasticity and their temperature dependence in commercial aluminum cast alloys were measured in the temperature range from room temperature (20°) to 250° by the resonant frequency method. The results obtained are as follows:
The modulus of longitudinal elasticity tended to decrease weakly and linearly (the tangent of its decrease, m = (-.4--3.3) × 10²kg//°) with the rise of temperature. Within the range of the experiments, aluminum cast alloys were divided into 3 groups, the lst group materials having large moduli of elasticity at room temperature (i. ., = (7.15-7.25) × 10⁵kg/) were ACA-T, AC3A-, AC4A-, AC4A-T4, AC4-, AC4-T4, ACA-, ACA-T4, etc., the nd group materials having intermediate moduli (i. ., = (.85-.98) × 10⁵kg/) were AC4-, AC4-T, AC4-T, AC4D-, AC4D-T, AC7A-, etc. and the 3rd group materials showing considerably smaller moduli (i. ., = (.58-.65) × 10⁵kg/) were AC1A-, AC1A-T, ACA-, etc. However, there were some differences between the moduli in this experiments and the moduli in the other data books, and these were considered due to the difference of the measurement principles and of hypotheses or assumptions involved in these principles, so it is suggested that the moduli of elasticity should be reported with indication of the measuring method.

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Six new cembranoids sarcophytol P (3), R (4), S (), K (), (11), and T (13) were isolated from the soft coral Sarcophyton glaucum. Sarcophytol P (3) was shown to be the 20-hydroxy derivative of the major component sarcophytol A (1), and afforded the cyclization product in CHCl_3 at room temperature, in a same way as in 1. Sarcophytols R (4) and S () were correlated to 1, by conversion of its 7R,R and 7S,S epoxide derivatives. Sarcophytol K() was a 13, 14-dihydroxycembranoid having a 1,3Z-diene moiety. The absolute configuration of and its 1Z,3- and 1Z,3Z-isomers sarcophytol () and J (10) were determined by circular dichroism study of their bis-p-dimethylaminobenzoate derivatives. Sarcophytols (11) and T (13) were 1- and 1,3Z-isomers of 1. Compound 11 showed characteristic broadening of the ^1H-NMR chemical shifts, due to the restricted conformational interconversion. Using the three cembranoids sarcophytols (11, 1,3), N (15, 1Z,3Z) and T (13,1,3Z), spontaneous autoxidation-cyclization, in CHCl_3,was examined, in order to compare the stereochemical course of the reaction with that of 1 (1Z,3), which affords trans-fused bicyclo[.3.]tetradecene systems. The 1,3Z-isomer 13 gave the same cyclization product 18, as in the reaction of 1, even though it is isomeric at -1,3. The 1Z,3Z isomer 15 gave 19, in consequence of the reversed geometry at -3 of 15. The 1,3-isomer (11) gave the bicyclic product , having an antipodal fusion as compared with 19. This was confirmed by PCC oxidation of 19 and , giving enantiomeric ketones 23 and 24 respectively. The 1(14)-epoxide 26 was shown to be the immediate precursor of , and acounted for the inversion of the geometry at -1 of the cyclization product. Compound 26 is isomeric with the epoxide 17 derived from 1. The epoxide 17 is the postulated precursor in the conversion of 13 to 18. It is noteworthy that the mode of antipodal fusion of the cyclopentane rings, in 18 and , was controlled by the chirality of the epoxy rings. The -14 hydroxyl group participates in the transannular cyclization, but was found not to be the requisite functional group for the reaction. Similar treatment of cembrene (30), the parent hydrocarbon of 1, also reacted in CHCl_3 giving the bicyclic product 32.

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Damage to reinforced concretc buildings in Niigata City due to Niigata earthquake (June 16, 1964) are analysed with special reference to foundation engineering.

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By employing an undrained cyclic loading ring-shear apparatus, a series of tests to reproduce the dynamic behavior of the Nikawa landslide induced by the January 17, 1995 Hyogoken-Nambu earthquake, is conducted. The test sample is Osaka-group coarse sandy soil taken from the landslide. The initial stress condition acting on a soil element in the sliding surface is applied to the sample. Based on the seismic records monitored at the JR Takarazuka Station, the input seismic wave is synthesized to reproduce the seismic stress acting on the sliding surface. The test results show that the soil failed due to the dynamic loading of the earthquake. The most important results are the excess pore water pressure generation and the acceleration of shear displacement continuing after the main shock. Combined with the grain crushing at the shear zone and the volume reduction in the drained constant-speed ring-shear test, the mechanism of this landslide is interpreted as, shear displacement causing grain crushing in the shear zone and volume reduction, and then resulting in a localized liquefaction phenomenon, "sliding-surface liquefaction". This geotechnical simulation test provides a reasonable interpretation of this highly mobile landslide.

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