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  • 佐藤 敬之輔
    デザイン学研究
    1970年 1970 巻 11 号 45-55
    発行日: 1970/03/30
    公開日: 2017/07/25
    ジャーナル フリー
    [1] The purpose of this reserch is to make clear what type of design can give good effects to win the high readership score. At the begining I had to know what factors decide the readership score, and how to change the quality of the desing into numerical value. I have used the method of multi-dimentional analysis with the help of a computer, and got the estimation formula, with
    7
    kinds of factors, as follows ; A^^〜=
    B
    +C+D+K+aE+
    bF
    +cG. A^^〜=estimated values of the readership score. 1)
    B
    , C, D, K : these four factors are given as category values (so we call them); each factor is classified into several categories.
    B
    =week day, classified into
    7
    categories. C=pages of a newspaper, which are characterized by the kinds of articles, news, and the other reading matters, classified into
    22
    categories. D=kinds of goods and trades of the advertizement, classified into 14 catedories. K=constants, given to each 13 surveys. 2)
    E
    ,
    F
    , G : these factors are given as numerical values. G=area of advertizement, measured by the unit of column in the whole page length, being classified into 6 kinds of area (2.5, 3.5, 5,
    7
    , 10, 15) and 15 column means a whole page, about 2,000cm^2.
    E
    ,
    F
    are the marks obtained in the design of advertizements.
    E
    =sum of the marks obtained in each design element on the advertizement.
    F
    =the marks obtained on the whole effect of the design. 3) a,
    b
    , c : coefficients Using the above formula with the category values and the coefficients, we can obtain the naked design effect from the actual value A of readership score: aE+
    bF
    =A-(
    B
    +C+D+K+cG). In this research, I used 1,829 data of readership score from 1960 to 1968, being obtained by 13 survevs, spring and autumn twice a year. The sample of size each survey was 3,541, 2,251, or 200 in the other 11 surveys. Multiple correlation coefficient between the estimated value A^^〜 and the actual value A is 0.951. The table 2^* shows the contribution indexes of each factor by 3 kinds of expression-(1) Range : the absolute difference between the maximum and the minimum category values, (2) Standard deviations of the category values, (3) Partial correlation coefficient : the relationship between the actual values A and each factors. *see the table 2 in the thesis in Japanese. [2] The important point was in the determination of the values of
    E
    ,
    F
    .
    E
    is the sum of the marks obtained in each design element, classified into four kinds :
    E
    =
    E
    _1+
    E
    _2+
    E
    _3+
    E
    _
    4
    . design elements [table]
    E
    _1,
    E
    _2,
    E
    _3,
    E
    _
    4
    , these values have the 5 grades, as 0, 1, 2, 3,
    4
    and 0 is given to the design that has no attractive effect or no applicable element. And
    E
    obtain the marks of 0 to
    9
    grades as the sum of them. The values of
    F
    have also 5 grades, 0 to
    4
    . The principles to determine the values of
    E
    ,
    F
    are as follows : a) The marks obtained of
    E
    ,
    F
    must be the relative values among the each survey, and at the same time, they must have constancy within the same survey-the same elements of design must win the same marks obtained.
    b
    ) They must be determined as to win the highest multiple correlation coefficient, when they are put into the estimation formula. c) They must be reasonable. In order to justify them, we must carry many researches on the actual condition. The frequency of accurence of each grade of
    E
    ,
    F
    values, as the table 5-
    4
    , and 5-5 in the thesis in Japanese.
  • George W. Lee
    燃料協会誌
    1973年 52 巻 3 号 171-177
    発行日: 1973/03/20
    公開日: 2010/06/28
    ジャーナル フリー
  • A.M. BRITTO, C. SAVVIDOU, M.J. GUNN, J.R. BOOKER
    土質工学会論文報告集
    1992年 32 巻 1 号 13-25
    発行日: 1992/03/15
    公開日: 2008/02/29
    ジャーナル フリー
    One method currently being considered for the disposal of high level radio-active waste is burial in the seabed. When a hot object is buried in soil, the temperature of the soil adjacent to the object is raised and there is transient heat flow away from the object. The rise in the temperature of the soil causes excess pore pressures to be generated and transient pore water diffusion also takes place. A finite element formulation of the coupled heat flow and consolidation problem is presented. The computer implementation of this formulation is found to compare favourably with analytical solutions based on the same physical principles.
  • Grover Loening
    日本航空学会誌
    1963年 11 巻 119 号 373-380
    発行日: 1963年
    公開日: 2009/05/25
    ジャーナル フリー
  • 小田切 孝人, 田代 眞人
    ウイルス
    2013年 63 巻 2 号 233-240
    発行日: 2013/12/25
    公開日: 2014/10/31
    ジャーナル フリー
  • Nobutoshi TANAKA, Ken-ichi HOSOI, Daizo TANAKA, Mimei TAKAHASHI
    Chemical and Pharmaceutical Bulletin
    1996年 44 巻 4 号 843-846
    発行日: 1996/04/15
    公開日: 2008/03/31
    ジャーナル フリー
    Chemical properties of ergosta-
    4
    , 6, 8(14),
    22
    -tetraen-3-one (1) were investigated. Though 1 is rather stable to acids or bases, it reacts easily with two moleculres of oxygen on irradiation with UV light to give 6α,
    -epidioxy-14α-hydroperoxyergosta-
    4
    ,
    7
    ,
    22
    -trien-3-one (2), which is transformed successively to 6α,
    ;8α,
    -diepoxy-14α-hydroperoxyergosta-
    4
    ,
    22
    -dien-3-one (3) and 14α-hydroperoxy-
    -hydroxyergosta-
    4
    ,
    7
    ,
    22
    -triene-3, 6-dione (
    4
    ) under these reaction conditions.
  • Özkan ASLANTAŞ, Ebru Şebnem YILMAZ
    Journal of Veterinary Medical Science
    2017年 79 巻 6 号 1024-1030
    発行日: 2017年
    公開日: 2017/06/16
    [早期公開] 公開日: 2017/04/27
    ジャーナル フリー

    This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant

    E
    . coli isolates were detected in 95 (
    22
    .2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: blaCTX-M-15 (62), blaTEM-
    1b
    (42), blaCMY-2 (
    22
    ), blaCTX-M-3 (16), blaCTX-M-1 (15), blaOXA-1 (
    9
    ) and blaSHV-12 (3) alone or in combination. The most frequently encountered phylogenetic group was group A1 (35.8%), followed by group D2 (
    22
    .1%),
    B
    1 (15.8%), D1 (
    9
    .5%), A0 (
    7
    .
    4
    %),
    B22
    (5.3%) and
    B23
    (
    4
    .2%), respectively. PMQR genes, aac(6’)-Ib-cr, qnrS1 and qnrB10 were detected in 25.3, 10.5 and 1.1% of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.0% for tobramycin to 56.8% for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE,
    f17a
    -A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing
    E
    . coli
    clone O25
    b
    :ST131/
    B
    2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing
    E
    . coli
    isolates among dogs in Turkey.

  • 木村 泰三, 錦野 光浩, 飯塚 一郎, 矢部 清寿, 岩中 督, 竹下 力, 甲田 安二郎
    日本臨床外科医学会雑誌
    1981年 42 巻 3 号 275-279
    発行日: 1981/05/01
    公開日: 2009/02/10
    ジャーナル フリー
    急性胆嚢炎の急性期手術の是非については,依然議論のあるところである.過去8年の当院外科での胆石胆嚢炎手術症例284例を,手術時期によって
    4
    群にわけ,平均手術時間(A),術中出血量(
    B
    ),手術死亡率(C),術後合併症発生率(D),遺残結石発生率(
    E
    ),手術から退院までの日数(
    F
    ),全入院日数(G)などを比較検討した.急性期(発作中あるいは発症後3日以内)に手術を施行された症例は36例で, A124分,
    B
    302ml, C2.8%, D11%,
    E
    3%,
    F
    19日, G
    22
    日であった.中間期(発症後
    4
    日~21日)に手術された症例は
    94
    例で, A132分,
    B
    259ml, C3.2%, D
    9
    %,
    E
    2%,
    F
    15日, G26日であった.それに対し間歇期(発作後
    22
    日以後)に手術された症例は140例で, A123分,
    B
    222ml, C1.
    4
    %, D
    7
    %,
    E
    2%,
    F
    15日, G34日であった.無症状胆石の手術症例は14例あるが,間歇期手術よりさらに良好な成績であった.
    以上の結果より,急性期手術はその安全性の点で間歇期手術に何ら劣るものでなく,入院期間を著しく短縮出来る利点があり,積極的に試みられるべき治療法と考えられた.
  • 村上 孝夫, 木村 毅, 和田 浩志, 田中 信寿, 斎木 保久, 陳 秋明
    Chemical and Pharmaceutical Bulletin
    1981年 29 巻 3 号 866-868
    発行日: 1981/03/25
    公開日: 2008/03/31
    ジャーナル フリー
    From the fronds of Polystichum tripteron (KUNZE) PR. a new norcarotenoid glycoside was isolated and shown to be (6R,
    7
    E
    ,
    9
    R)-
    9
    -hydroxy-megastigma-
    4
    ,
    7
    -dien-3-one-
    9
    -O-β-D-glucoside. The fronds of Dennstaedtia wilfordii (MOORE) CHRIST. contain the same glucoside.
  • 斎藤 徹, 井上 勲, 藤井 澄三
    Chemical and Pharmaceutical Bulletin
    1990年 38 巻 6 号 1536-1547
    発行日: 1990/06/25
    公開日: 2008/03/31
    ジャーナル フリー
    A full account is given of the chemical behavior observed for
    7
    ,
    9
    -dialkyladeninium salts (16). On treatment with boiling 1N aqueous NaOH for 60min, 16a,
    b
    , d,
    e
    (X=I), 16c (X=Br), and 16
    f
    (X=
    ClO4
    ) rearranged to isomeric N6,
    7
    -dialkyladenines (21a-
    f
    ) in 50-91% yields. Treatment of the salts with 0.5N aqueous Na2CO3 at room temperature for 30-90min or with Amberlite CG-400 (OH-) in H2O at room temperature gave the ring-opened derivatives
    22
    a-
    f
    (in the trans-formamide form) in 56-83% yields, and rate constants for the ring-opening reactions of 16a,
    b
    , d-g (X=
    ClO4
    ) and 16c (X=Br) leading to
    22
    a-g were determined in H2O at pH
    9
    .84 and ionic strength 0.50 at 25°C. Cyclization of
    22
    a with NaH in AcNMe2 at room temperature or with boiling 1N aqueous NaOH produced 21a in 84% or 72% yield, respectively.In solution, the trans-formamides
    22
    seemed to transform slowly into the cis-formamides 23, attaining equilibria. The existence of such an equilibrium in D2O or Me2SO-d6 at 25°C or in H2O at pH
    9
    .84 and ionic strength 0.50 at 25°C was kinetically confirmed in the case of
    22
    a, and the mechanism of the rearrangement of 16 to 21 through
    22
    is discussed on the basis of the above kinetic results and Deslongchamps' theory of stereoelectronic control. On treatment with
    NaBH4
    in MeOH at room temperature, 16a (X=I) furnished the
    7
    , 8-dihydro derivative 28 (84% yield), which slowly decomposed in H2O at 60°C to give
    22
    a in 49% yield.The
    7
    ,
    9
    -dialkyladeninium salts (16) were found to be obtainable from N'-alkoxy-1-alkyl-5-formamidoimidazole-
    4
    -carboxamidines (
    9
    ) through an alternative synthetic route : Alkylations of
    9
    with alkyl halides in HCONMe2 in the absence of base, followed by hydrogenolysis of the N'-alkoxy group and cyclizatio (or vice versa) produced 16 in acceptable yields. In order to interpret the proton nuclear magnetic resonance spectrum of
    22
    a, the 2-deuterated species 26 was also synthesized from 24 via 25 and 27.
  • 健常成人を対象として
    和田 佳郎, 藤田 信哉, 康 勲, 上田 隆志, 松永 喬
    耳鼻咽喉科臨床 補冊
    1990年 1990 巻 Supplement37 号 71-77
    発行日: 1990/03/20
    公開日: 2012/11/27
    ジャーナル フリー
    This study was performed to clarify the hemodynamic of vertebral and common carotid arteries of normal subjects by ultrasonic doppler method. Subjects were 51 in all, i.
    e
    .,41males and 10 females, between
    22
    and 64 years old.
    For the vertebral artery, mean blood velocity (BV) was
    9
    .
    4
    ± 3.5 cm/s, mean blood flow volume (
    BF
    ) was 1.6 ± 0.6 ml/s and mean vessel diameter (VD) was
    4
    .6 -± 0.5 mm. On the other hand, for the common carotid arteries, BV was 31.5±55.2.2 cm/s,
    BF
    was 14.0±3.2 ml/s and VD was
    7
    .5 -±0.6 mm. BV of the vertebral arteries increased in the elderly, whereas BV of the common carotid arteries decreased in the elderly.
  • 伊藤 大介
    日本物理学会講演概要集
    1997年 52.2.1 巻 22a-E-9
    発行日: 1997/09/02
    公開日: 2018/03/04
    会議録・要旨集 フリー
  • Takeshi ITABASHI, Nobuko OGASAWARA, Koohei NOZAWA, Ken-ichi KAWAI
    Chemical and Pharmaceutical Bulletin
    1996年 44 巻 12 号 2213-2217
    発行日: 1996/12/15
    公開日: 2008/03/31
    ジャーナル フリー
    Three new azaphilone derivatives designated falconensins
    E
    5 (5),
    F
    (6), and G (
    7
    ) were isolated from the mycelium o Emericella falconensis, along with falconensins A (1),
    B
    (2), C (3), D (
    4
    ), and H (8), and three hopane-type triterpenes, zeorin (
    9
    ), hepane-
    ,
    22
    -diol (10), and hopane-6α,
    ,
    22
    -triol (11). The structures of 5-
    7
    were confirmed by spectroscopic investigation and chemical correlations. The absolute stereochemistry of falconensins A (1) to G(
    7
    ) was also established.
  • 林 雄二, 松本 武
    天然有機化合物討論会講演要旨集
    1981年 24 巻 42
    発行日: 1981/09/10
    公開日: 2017/08/18
    会議録・要旨集 フリー
    Reactions of nor-diterpenoid dilactones isolated from Podocarpus plants have been investigated. The
    7
    : 8,
    9
    : 11-dienolide type [C] dilactones, the least available but biologically the most active members, are mainly derived from naturally abundant dilactone components of α-pyrone type [A] and
    7
    : 8-epoxy-
    9
    : 11-enolide type [
    B
    ] for total-synthetic and biological purposes. From nagilactone
    E
    (5), for example, a combined sequence of hydrogenolysis of
    7
    : 8-epoxide group and dehydration gives nagilactone
    F
    (
    7
    ), 3β-hydroxynagilactone
    F
    (8) and 2: 3-dehydronagilactone
    F
    (19), which have been found from natural sources. From nagilactone A (1), photo-hydration and concomitant double bond migration of its acetate results in a lactol (
    22
    ), which is reduced to 1β-hydroxynagilactone
    F
    (
    9
    ), another natural type [C] dilactone. Derivation of the type [A] or [
    B
    ] from others is not successful. Some attempts for conversion of the ring A functional groups have also been studied.
  • Takaaki ISHIZUKA, Yasunori YAOITA, Masao KIKUCHI
    Chemical and Pharmaceutical Bulletin
    1997年 45 巻 11 号 1756-1760
    発行日: 1997/11/15
    公開日: 2008/03/31
    ジャーナル フリー
    Four new sterols, 5α, 6α-epoxy-(
    22
    E
    , 24R)-ergosta-8(14),
    22
    -diene-3β,
    -diol (1), (
    22
    E
    , 24R)-ergosta-8,
    22
    -diene-3β, 5α, 6β,
    -tetrol (2), (
    22
    E
    , 24R)-ergosta-
    7
    ,
    9
    (11),
    22
    -triene-3β, 5α, 6β-triol (3) and 3β, 5α, 6β-trihydroxy-(
    22
    E
    , 24R)-ergost-
    22
    -en-
    7
    -one (
    4
    ), have been isolated from the fruit bodies of Grifola frondosa (FR.) S.
    F
    . GRAY (Polyporaceae)together with fourteen known ones (5-18), of which two (5 and 6) are reported for the first time from a natural source. The structures of these compounds were elucidated on the basis of spectral data.
  • 小林 優, 家坂 貴子, 中野 江身子, 平山 耕一郎
    天然有機化合物討論会講演要旨集
    1989年 31 巻 71/P2-1
    発行日: 1989/09/17
    公開日: 2017/08/18
    会議録・要旨集 フリー
    Six new cembranoids sarcophytol P (3), R (
    4
    ), S (5), K (8),
    F
    (11), and T (13) were isolated from the soft coral Sarcophyton glaucum. Sarcophytol P (3) was shown to be the 20-hydroxy derivative of the major component sarcophytol A (1), and afforded the cyclization product 6 in CHCl_3 at room temperature, in a same way as in 1. Sarcophytols R (
    4
    ) and S (5) were correlated to 1, by conversion of its
    7
    R,8R and
    7
    S,8S epoxide derivatives. Sarcophytol K(8) was a 13, 14-dihydroxycembranoid having a 1
    E
    ,3Z-diene moiety. The absolute configuration of 8 and its 1Z,3
    E
    - and 1Z,3Z-isomers sarcophytol
    B
    (2) and J (10) were determined by circular dichroism study of their bis-p-dimethylaminobenzoate derivatives. Sarcophytols
    F
    (11) and T (13) were 1
    E
    - and 1
    E
    ,3Z-isomers of 1. Compound 11 showed characteristic broadening of the ^1H-NMR chemical shifts, due to the restricted conformational interconversion. Using the three cembranoids sarcophytols
    F
    (11, 1
    E
    ,3
    E
    ), N (15, 1Z,3Z) and T (13,1
    E
    ,3Z), spontaneous autoxidation-cyclization, in CHCl_3,was examined, in order to compare the stereochemical course of the reaction with that of 1 (1Z,3
    E
    ), which affords trans-fused bicyclo[
    9
    .3.0]tetradecene systems. The 1
    E
    ,3Z-isomer 13 gave the same cyclization product 18, as in the reaction of 1, even though it is isomeric at C-1,3. The 1Z,3Z isomer 15 gave 19, in consequence of the reversed geometry at C-3 of 15. The 1
    E
    ,3
    E
    -isomer (11) gave the bicyclic product
    22
    , having an antipodal fusion as compared with 19. This was confirmed by PCC oxidation of 19 and
    22
    , giving enantiomeric ketones 23 and 24 respectively. The 1(14)-epoxide 26 was shown to be the immediate precursor of
    22
    , and acounted for the inversion of the geometry at C-1 of the cyclization product. Compound 26 is isomeric with the epoxide 17 derived from 1. The epoxide 17 is the postulated precursor in the conversion of 13 to 18. It is noteworthy that the mode of antipodal fusion of the cyclopentane rings, in 18 and
    22
    , was controlled by the chirality of the epoxy rings. The C-14 hydroxyl group participates in the transannular cyclization, but was found not to be the requisite functional group for the reaction. Similar treatment of cembrene C (30), the parent hydrocarbon of 1, also reacted in CHCl_3 giving the bicyclic product 32.
  • I.
    F
    . Davies
    Journal of Light & Visual Environment
    1984年 8 巻 1 号 1_9-1_20
    発行日: 1984年
    公開日: 2011/05/20
    ジャーナル フリー
  • 林 雄二, 松本 武, 西沢 麦夫, 兵野 敏明, 西川 直見, 植村 元一, 戸上 昌紀, 目 武雄
    天然有機化合物討論会講演要旨集
    1979年 22 巻 17
    発行日: 1979/09/20
    公開日: 2017/08/18
    会議録・要旨集 フリー
    Nagilactone
    F
    (1), one of the simplest member of the biologically active nor-diterpenoid dilactones of Podocarpus nagi, was first synthesized from (+)-[
    4
    S]-podocarpic acid (2). Ozonolysis of a 14-isopropyl-enone 10, derived from (+)-podocarpic acid in several steps, gave a keto-acid 12. The acid 12 was transformed into epimeric (at C-14) enolides,
    22
    and 23, via reductive lactonization and subsequent dehydrogenation. The two enolides gave the same diene-acid 24 on treatment with KOtBu in DMSO. Stereospecific lactonization of 24 to 14α-isopropyl-8:
    9
    -enolide 25 was achieved photochemically under irradiation in ethanol solution. On dehydrogenation with DDQ/
    BF
    _3:ether in refluxing dioxane, 25 gave a dienolide 27, which equipped with suitable functional groups and stereochemistry on the ring C necessary for nagilactone
    F
    . The dienolide ester 27 was hydrolyzed with conc. H_2SO_
    4
    to form a dienolide acid 28, which was successfully changed to nagilactone
    F
    by Pb(OAc)_
    4
    oxidation. Reductive degradation of nagilactone
    F
    to the synthetic intermediates, 28, 25 and 24, was also done, starting from nagilactone
    E
    , a typical natural dilactone of P. nagi.
  • Hin-chung Wong, Chia-Yun Ho, Li-Ping Kuo, Tien-Kuei Wang, Chi-Lung Lee, Daniel Yang-Chih Shih
    MICROBIOLOGY and IMMUNOLOGY
    1999年 43 巻 7 号 631-636
    発行日: 1999年
    公開日: 2008/03/17
    ジャーナル フリー
    Vibrio parahaemolyticus is a prevalent food-borne pathogen in Taiwan, Japan and other Asian countries. This work presents a novel ribotyping method for the molecular epidemiological examination of this pathogen. Genomic DNA was fragmented by HindIII digestion and hybridized with cDNA probe for Escherichia coli 16S and 23S RNA genes. A total of 121 isolates obtained from outbreaks during 1992 and 1994 in Taiwan were characterized by this ribotyping method. Four to seventeen restricted fragments were visualized in these isolates. After hierarchical cluster analysis, these isolates were grouped into thirty different ribotypes. In addition, A3, A
    7
    ,
    E
    3 and
    F
    1 were the major ribotypes, consisting of
    22
    .3, 13.2,
    9
    .1, and 8.3% of the isolates, respectively. A,
    E
    ,
    F
    , G and
    B
    were the major groups, consisting of 46.2, 14.0,
    9
    .1, 6.
    7
    , and 6.
    7
    % of the isolates, respectively. The discriminatory ability of this ribotyping method, as determined by Simpson's index of diversity, was 0.93, which closely resembled that of a previously reported pulsed-field gel electrophoresis method.
  • 高津戸 秀, 池川 信夫
    Chemical and Pharmaceutical Bulletin
    1984年 32 巻 5 号 2001-2004
    発行日: 1984/05/25
    公開日: 2008/03/31
    ジャーナル フリー
    Brassinolide analogues, (
    22
    R, 23R, 24R)-2α, 3α,
    22
    , 23-tetrahydroxy-
    B
    -homo-
    7
    -oxa-5α-ergostan-6-one (24-epibrassinolide) (10) and (
    22
    S, 23S, 24R)-2α, 3α,
    22
    , 23-tetrahydroxy-
    B
    -homo-
    7
    -oxa-5α-ergostan-6-one (
    9
    ), were synthesized from brassicasterol (3a) in five steps and with ca. 20% overall yield. The key steps are the direct formation of (
    22
    E
    , 24R)-3α, 5-cyclo-5α-ergost-
    22
    -en-6-one (
    4
    ) from brassicasterol mesylate (3
    b
    ), the acid-catalyzed rearrangement of
    4
    to (
    22
    E
    , 24R)-5α-ergosta-2,
    22
    -dien-6-one (6), and the Baeyer-Villiger oxidation of the tetrahydroxy 5α-ergostan-6-ones
    7
    and 8.
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