Inhibitory Effect of Alginic Acids on Hyaluronidase and on Histamine Release from Mast Cells

Masahiro ASADA; Makiko SUGIE; Mami INOUE; Kazuya NAKAGOMI; Seiji HONGO; Katsumi MURATA; Shinji IRIE; Toshio TAKEUCHI; Noboru TOMIZUKA; Syuichi OKA

doi:10.1271/bbb.61.1030

Masahiro ASADA, Makiko SUGIE, Mami INOUE, Kazuya NAKAGOMI, Seiji HONGO, Katsumi MURATA, Shinji IRIE, Toshio TAKEUCHI, Noboru TOMIZUKA, Syuichi OKA

Author information

Masahiro ASADA
Makiko SUGIE
Mami INOUE
Kazuya NAKAGOMI
Seiji HONGO
Katsumi MURATA
Shinji IRIE
Toshio TAKEUCHI
Noboru TOMIZUKA
Syuichi OKA
Author's Organization：
National Institute of Bioscience and Human-Technology
National Institute of Bioscience and Human-Technology
National Institute of Bioscience and Human-Technology
Toyama Medical and Pharmaceutical Uliversity
Toyama Medical and Pharmaceutical Uliversity
Kibun Food Chemifa Co., Ltd.
Kibun Food Chemifa Co., Ltd.
Kibun Food Chemifa Co., Ltd.
National Institute of Bioscience and Human-Technology
National Institute of Bioscience and Human-Technology

Keywords: alginic acid, uronic acid, inhibitor, hyaluronidase, mast cell degranulation

JOURNAL FREE ACCESS

1997 Volume 61 Issue 6 Pages 1030-1032

DOI https://doi.org/10.1271/bbb.61.1030

Details

Abstract

The effects of various types of alginic acid consisting of L-guluronic acids (G) and D-mannuronic acids (M) on hyaluronidase and mast cell degranulation were examined. Alginic acid with an M/G ratio of 1.0 exhibited the strongest inhibition of both activities, the higher molecular weight alginic acids of 150 to 370kDa being preferable in both cases. Esterification of the carboxyl residue enhanced the latter activity.

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