Apoptosis to HL-60 by Humulone

Hiroyasu TOBE; Mitsuaki KUBOTA; Mitsune YAMAGUCHI; Tomoji KOCHA; Takaaki AOYAGI

doi:10.1271/bbb.61.1027

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Apoptosis to HL-60 by Humulone

Hiroyasu TOBE, Mitsuaki KUBOTA, Mitsune YAMAGUCHI, Tomoji KOCHA, Takaaki AOYAGI

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Keywords: apoptosis, bone resorption inhibitor, humulone, antioxidant, HL-60

JOURNAL FREE ACCESS

1997 Volume 61 Issue 6 Pages 1027-1029

DOI https://doi.org/10.1271/bbb.61.1027

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Abstract

Humulone, a bone resorption inhibitor isolated from hop extract, induced apoptosis in the premyocytic leukemia cell line HL-60 between 1 and 100μg/ml. Our data suggested that there was a correlation between the apoptosis-inducing activity of humulone and its antioxidative activity.

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