New Biologically Active Marine Sesquiterpenoid and Steroid from the Okinawan Sponge of the Genus Axinyssa

Makoto Iwashima; Ikuo Terada; Kazuo Iguchi; Takao Yamori

doi:10.1248/cpb.50.1286

Notes

New Biologically Active Marine Sesquiterpenoid and Steroid from the Okinawan Sponge of the Genus Axinyssa

Makoto Iwashima, Ikuo Terada, Kazuo Iguchi, Takao Yamori

Author information

Keywords: marine sponge, genus Axinyssa, bisabolane sesquiterpenoid, 5α,8α-epidioxysterol

JOURNAL FREE ACCESS

2002 Volume 50 Issue 9 Pages 1286-1289

DOI https://doi.org/10.1248/cpb.50.1286

Details

Abstract

A new bisabolane-type sesquiterpenoid, (E)-3-isocyanobisabolane-7,10-diene (1), and a new epidioxyergostane-type steroid, 9(11)-dehydroaxinysterol (2), were isolated from the Okinawan sponge of the genus Axinyssa. Their structures were elucidated based on the results of spectroscopic analysis and chemical conversion. Epidioxysterol 2 was found to show significant growth inhibitory effects against human cancer cell lines.

Corresponding author

Register with J-STAGE for free!