Myeloperoxidase Inhibitory and Radical Scavenging Activities of Flavones from Pterogyne nitens

Daniara Cristina Fernandes; Luis Octávio Regasini; José Carlos Rebuglio Vellosa; Patrícia Mendonça Pauletti; Ian Castro-gamboa; Vanderlan Silva Bolzani; Olga Maria Mascarenhas Oliveira; Dulce Helena Siqueira Silva

doi:10.1248/cpb.56.723

Notes

Myeloperoxidase Inhibitory and Radical Scavenging Activities of Flavones from Pterogyne nitens

Daniara Cristina Fernandes, Luis Octávio Regasini, José Carlos Rebuglio Vellosa, Patrícia Mendonça Pauletti, Ian Castro-gamboa, Vanderlan Silva Bolzani, Olga Maria Mascarenhas Oliveira, Dulce Helena Siqueira Silva

Author information

Daniara Cristina Fernandes
NuBBE-Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Department of Organic Chemistry, Institute of Chemistry, UNESP-São Paulo State University
Luis Octávio Regasini
NuBBE-Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Department of Organic Chemistry, Institute of Chemistry, UNESP-São Paulo State University
José Carlos Rebuglio Vellosa
Department of Biochemistry and Chemical Technology, Institute of Chemistry, UNESP-São Paulo State University
Patrícia Mendonça Pauletti
Department of Biochemistry and Chemical Technology, Institute of Chemistry, UNESP-São Paulo State University
Ian Castro-gamboa
NuBBE-Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Department of Organic Chemistry, Institute of Chemistry, UNESP-São Paulo State University
Vanderlan Silva Bolzani
NuBBE-Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Department of Organic Chemistry, Institute of Chemistry, UNESP-São Paulo State University
Olga Maria Mascarenhas Oliveira
Department of Biochemistry and Chemical Technology, Institute of Chemistry, UNESP-São Paulo State University
Dulce Helena Siqueira Silva
NuBBE-Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Department of Organic Chemistry, Institute of Chemistry, UNESP-São Paulo State University

Keywords: flavone, Pterogyne nitens, myeloperoxidase, antioxidant, radical scavenging

JOURNAL FREE ACCESS

2008 Volume 56 Issue 5 Pages 723-726

DOI https://doi.org/10.1248/cpb.56.723

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Abstract

Two new flavone glucosides, nitensosides A and B (1, 2), together with four known compounds, sorbifolin (3), sorbifolin 6-O-β-glucopyranoside (4), pedalitin (5), and pedalitin 6-O-β-glucopyranoside (6) were isolated from Pterogyne nitens. Their structures were elucidated from 1D and 2D NMR analysis, as well as by high resolution mass spectrometry. All the isolated flavones were evaluated for their myeloperoxidase (MPO) inhibitory activity. The most active compound, pedalitin, exhibited IC₅₀ value of 3.75 nM on MPO. Additionally, the radical-scavenging capacity of flavones 1—6 was evaluated towards ABTS and DPPH radicals and compared to standard compounds quercetin and Trolox^®.

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