Inhibitory Effects of Acylated Acyclic Sesquiterpene Oligoglycosides from the Pericarps of Sapindus rarak on Tumor Necrosis Factor-α-Induced Cytotoxicity

Toshio Morikawa; Yuanyuan Xie; Kiyofumi Ninomiya; Masaki Okamoto; Osamu Muraoka; Dan Yuan; Masayuki Yoshikawa; Takao Hayakawa

doi:10.1248/cpb.58.1276

Notes

Inhibitory Effects of Acylated Acyclic Sesquiterpene Oligoglycosides from the Pericarps of Sapindus rarak on Tumor Necrosis Factor-α-Induced Cytotoxicity

Toshio Morikawa, Yuanyuan Xie, Kiyofumi Ninomiya, Masaki Okamoto, Osamu Muraoka, Dan Yuan, Masayuki Yoshikawa, Takao Hayakawa

Author information

Toshio Morikawa
Pharmaceutical Research and Technology Institute, Kinki University
Yuanyuan Xie
Pharmaceutical Research and Technology Institute, Kinki University
School of Traditional Chinese Medicine, Shenyang Pharmaceutical University
Kiyofumi Ninomiya
Pharmaceutical Research and Technology Institute, Kinki University
Masaki Okamoto
Pharmaceutical Research and Technology Institute, Kinki University
Osamu Muraoka
Pharmaceutical Research and Technology Institute, Kinki University
Dan Yuan
School of Traditional Chinese Medicine, Shenyang Pharmaceutical University
Masayuki Yoshikawa
Pharmaceutical Research and Technology Institute, Kinki University
Kyoto Pharmaceutical University
Takao Hayakawa
Pharmaceutical Research and Technology Institute, Kinki University

Keywords: Sapindus rarak, acyclic sesquiterpene oligoglycoside, tumor necrosis factor-α, Sapindaceae, Thai natural medicine

JOURNAL FREE ACCESS

2010 Volume 58 Issue 9 Pages 1276-1280

DOI https://doi.org/10.1248/cpb.58.1276

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Abstract

Four new acylated acyclic sesquiterpene oligoglycosides (1—4) were isolated from the pericarps of Sapindus rarak DC. together with four known acyclic sesquiterpene oligoglycosides, mukuroziosides Ia (5), Ib (6), IIa (7), and IIb (8). Their structures were elucidated on the basis of chemical and physicochemical evidence. These newly isolated compounds (1—4) were found to show inhibitory effects on tumor necrosis factor-α-induced cytotoxicity in L929 cells at concentrations of 30—100 μM.

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