Microbial Conversion of Curcumin into Colorless Hydroderivatives by the Endophytic Fungus Diaporthe sp. Associated with Curcuma longa

Shoji Maehara; Michiteru Ikeda; Hiroyuki Haraguchi; Chinami Kitamura; Tetsuro Nagoe; Kazuyoshi Ohashi; Hirotaka Shibuya

doi:10.1248/cpb.59.1042

Notes

Microbial Conversion of Curcumin into Colorless Hydroderivatives by the Endophytic Fungus Diaporthe sp. Associated with Curcuma longa

Shoji Maehara, Michiteru Ikeda, Hiroyuki Haraguchi, Chinami Kitamura, Tetsuro Nagoe, Kazuyoshi Ohashi, Hirotaka Shibuya

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Keywords: microbial conversion, curcumin, endophytic fungus, Diaporthe species, Curcuma longa

JOURNAL FREE ACCESS

2011 Volume 59 Issue 8 Pages 1042-1044

DOI https://doi.org/10.1248/cpb.59.1042

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Abstract

We investigated the microbial conversion of curcumin (1) using endophytic fungi associated with the rhizome of Curcuma longa (Zingiberaceae). We found that Diaporthe sp., an endophytic filamentous fungus, converts curcumin (1) into four colorless derivatives, namely (3R,5R)-tetrahydrocurcumin (2), a novel (3R,5S)-hexahydrocurcumin (3) named neohexahydrocurcumin, (3S,5S)-octahydrocurcumin (4) and meso-octahydrocurcumin (5).

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