1, 3-Oxazines and Related Compounds. XII. : Facile Synthesis of 2, 4-Disubstituted 6H-1, 3-Oxazin-6-ones

Abstract

A convenient method for synthesis of 2, 4-disubstituted 6H-1, 3-oxazin-6-ones (8) was developed. Acylaminoalkylidene-1, 3-dioxane-4, 6-diones (5a-1), which were prepared from N-acylimidates(3a-1) and Meldrum's acid (4), readily underwent thermolysis upon heating, leading to a variety of 2, 4-disubstituted 6H-1, 3-oxazin-6-ones (8a-1).