Metabolism of Paeoniflorin and Related Compounds by Human Intestinal Bacteria. IV. : Formation and Structure of Adducts of a Metabolic Intermediate with Sulfhydryl Compounds by Lactobacillus brevis

Abstract

Paeoniflorin from peony roots was converted to new compounds in the presence of various sulfhydryl compounds by Lactobacillus brevis. The compounds formed in the presence of 3-mercaptopropionic acid, 2-mercaptoethanol and thiobenzoic acid were determined to be 7R and 7S mixture of 8-(2-carboxyethylthio)paeonimetabolin I, 8-(2-hydroxyethylthio)paeonimetabolin I and 8-benzoylthiopaeonimetabolin I, respectively, by various spectroscopic methods. These compounds are adducts of a metabolic intermediate of paeoniflorin with the sulfhydryl compounds.