1992 Volume 40 Issue 10 Pages 2639-2646
Two new lignan glycosides, named hazaleanin A (1) and hazaleanin B (2), and two new apioglucosides, named isopropyl apioglucoside (3) and 4-hydroxyguaiacol apioglucoside (4), were isolated from the bark of Fagara rhetza (Rutaceae), an Indonesian medicinal plant from Flores Island, Indonesia. The chemical structures of 1, 2, 3, and 4 have been elucidated on the basis of chemical and physicochemical evidence, including a chiral synthesis of an aglycone derivative of 1.