Russuphelins B, C, D, E and F, New Cytotoxic Substances from the Mushroom Russula subnigricans HONGO

Akira TAKAHASHI; Tsutomu AGATSUMA; Tomihisa OHTA; Tetsuji NUNOZAWA; Takeshi ENDO; Shigeo NOZOE

doi:10.1248/cpb.41.1726

Akira TAKAHASHI, Tsutomu AGATSUMA, Tomihisa OHTA, Tetsuji NUNOZAWA, Takeshi ENDO, Shigeo NOZOE

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Keywords: Russula subnigricans, russuphelin, cytotoxic substance, mushroom, basidiomycete, 2, 6-dichloro-1, 4-hydroquinone

JOURNAL FREE ACCESS

1993 Volume 41 Issue 10 Pages 1726-1729

DOI https://doi.org/10.1248/cpb.41.1726

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Abstract

Five new chlorinated phenyl ethers, russuphelins B (2), C (3), D (4), E (5) and F (6) have been isolated from the mushroom Russula subnigricans HONGO, and their structures were elucidated by spectroscopic and chemical means. Russuphelins B (2), C (3) and D (4) exhibited cytotoxic activity in vitro against P388 leukemia cells.

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