SYNTHESES AND ANTIULCER ACTIVITIES OF NOVEL 2-[(6, 7, 8, 9-TETRAHYDRO-5H-CYCLOHEPTA[b]PYRIDIN-9-YL)SULFINYL]-1H-BENZIMIDAZOLE ANALOGUES

Shin-ichi YAMADA; Takao GOTO; Eiji SHIMANUKI; Sen-ichi NARITA

doi:10.1248/cpb.42.718

Shin-ichi YAMADA, Takao GOTO, Eiji SHIMANUKI, Sen-ichi NARITA

Author information

Keywords: (H⁺+K⁺)-ATPase inhibitor, TY-11345, diastereoisomeric mixture isomerization, antisecretory activity, 2-[(cyclohepta[b]pyridin-9-yl)sulfinyl]-1H-benzimidazole

JOURNAL FREE ACCESS

1994 Volume 42 Issue 3 Pages 718-720

DOI https://doi.org/10.1248/cpb.42.718

Details

Abstract

A synthetic study on a series of benzimidazole derivatives including cycloalka[b]pyridine moiety has been carried out. Among these compounds synthesized, a novel antipeptic agent with 6, 7, 8, 9-tetrahydro-5H-cyclohepta[b]pyridine moiety (TY-11345) was found to be superior to omeprazole in (H⁺+K⁺)-ATPase inhibitory activity and antisecretory potencies.

Corresponding author

Register with J-STAGE for free!