Isolation of Inhibitors of TPA-Induced Mouse Ear Edema from Hoelen, Poria cocos

Haruo NUKAYA; Hirokazu YAMASHIRO; Hirotatsu FUKAZAWA; Hitoshi ISHIDA; Kuniro TSUJI

doi:10.1248/cpb.44.847

Haruo NUKAYA, Hirokazu YAMASHIRO, Hirotatsu FUKAZAWA, Hitoshi ISHIDA, Kuniro TSUJI

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Keywords: ear edema, 12-O-tetradecanoylphorbol 13-acetate, Hoelen, 3β, 16α-dihydroxylanosta-7, 9(11), 24-trien-21-oic acid, 6α-hydroxydehydropachymic acid, 16α-hydroxytrametenolic acid

JOURNAL FREE ACCESS

1996 Volume 44 Issue 4 Pages 847-849

DOI https://doi.org/10.1248/cpb.44.847

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Abstract

Triterpene carboxylic acids were isolated from the methanol extract of Hoelen, Poria cocos, and found to inhibit 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse ear edema. Their chemical structures were identified as 3β, 16α-dihydroxylanosta-7, 9(11), 24-trien-21-oic acid, 16α-hydroxydehydropachymic acid, 16α-hydroxytrametenolic acid and dehydrotumulosic acid.

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