Detoxication and Excretion of Radioactive Strontium. III. Effect of Tricarballylic and Lactic Acids.

Abstract

Sodium tricarballylate (8.5 m.mole/kg.) activates the excretion of radioactive strontium injected and reduces its skeketal accumulation. Under a similar condition, sodium lactate (13.5 m.mole/kg.×4) is ineffective. Mechanism of active excretion caused by the injection of tricarballylate was discussed and suggested to be due to its chelating action. Some side effect of tricarballylate injection was observed but it did not produce severe injury.