-
Takeichi Sakaguchi, Masahiko Toma, Tomoko Yoshida, Hiroshi Omura, Hisa ...
1958 Volume 6 Issue 1 Pages
1-9
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
Terramycin and Achromycin form chelate compounds with various metals, especially stable compounds with zirconium and thorium, as previously reported with Aureomycin. Their molar ratio is 1:1 in thorium chelates and 1:2 in zirconium chelates. Further investigations on the chelate formation of Apoterramycin and Isoaureomycin showed that phenolic β-diketone in tetracycline structure was very important as the chelating group, as was indicated in the previous paper. It is also suggested that the chelation of tetracylines must further involve the 12-1 bond.
View full abstract
-
Koiti Kimura, Akira Tanaka
1958 Volume 6 Issue 1 Pages
9-12
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
Seventeen kinds of 3, 3-dimethylated branched fatty acids were prepared by anodic synthesis. Methyl or ethyl hydrogen 3, 3-dimethylglutarate was used as the half-ester of dibasic acid. Cross-coupled products were obtained by crossing half-ester with monobasic acids. Platinum plates were used as the electrodes, and methanol or ethanol as the solvent. The lower members of the series (up to C
16H
33O
2) are liquid, while the higher members (up to C
22H
46O
2) are solid. No alternation was seen in the melting points of these acids.
View full abstract
-
Hidetoshi Yoshimura
1958 Volume 6 Issue 1 Pages
13-15
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
Two isomeric hydroxyl compounds, m.p. 213∼215°(decomp.) and m.p. 143∼143.5°, were obtained by reduction of 3-keto-MHB (5-(3-oxo-1-cyclohexenyl)-3, 5-dimethylbarbituric acid) and those were identical in all respects with the amjor urinary metabolites, the diastereoisomeric (+)-α-and (+)-β-3-OH-MHB (5-(3-hydroxy-1-cyclohexenyl)-3, 5-dimethylbarbituric acid), respectively, except the optical property. Pharmacological activity of four main metabolites of MHB obtained previously were also examined but none showed any hypnotic action.
View full abstract
-
Hisao Tsukamoto, Hidetoshi Yoshimura, Satoshi Toki
1958 Volume 6 Issue 1 Pages
15-18
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
Examination of urinary product of rabbits administered with MHB, by filter paper chromatography, indicated that ureide, 3-OH-MHB, 3-keto-MHB, 3-keto-nor-MHB, and unknown compounds (MHB-M (VI)) were excreted. An excellent method for the separation of these compounds is the use of a buffered filter paper and butanol saturated with borate-NaOH buffer (pH 11). For detection of the located metabolites, 1% solution of sodium periodate and 1% solution of potassium permanganate were used and ultraviolet spectrophotometry was adopted for the characterization of barbiturates.
View full abstract
-
Osamu Tanaka
1958 Volume 6 Issue 1 Pages
18-24
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
The infrared spectra of about 80 anthraquinone derivatives substituted with acetoxyl, hydroxyl, methoxyl, or methyl group, were measured in the dioxane solution and in the solid state. The effect of substituents on the free and chelated C=O stretching vibration frequencies was discussed.
View full abstract
-
Osamu Tanaka
1958 Volume 6 Issue 1 Pages
24-30
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
The infrared spectra of about 80 anthraquinone derivatives substituted with acetoxyl, hydroxyl, methoxyl, and methyl groups were measured as a solid and in solution. The effect of the substituents to the position and intensity of the absorption band in the region of 1480∼1620cm
-1 was discussed.
View full abstract
-
Kono Kinoshita, Shoichi Nakajima
1958 Volume 6 Issue 1 Pages
31-33
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
Itaconitin, a yellow pigment from Aspergillus itaconicus, was preliminarily examined for the elucidation of its structural formula.
View full abstract
-
Yosoji Ito, Susumu Tsurufuji, Sadahiko Ishibashi, Morizo Ishidate, Zen ...
1958 Volume 6 Issue 1 Pages
34-36
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
Sodium tricarballylate (8.5 m.mole/kg.) activates the excretion of radioactive strontium injected and reduces its skeketal accumulation. Under a similar condition, sodium lactate (13.5 m.mole/kg.×4) is ineffective. Mechanism of active excretion caused by the injection of tricarballylate was discussed and suggested to be due to its chelating action. Some side effect of tricarballylate injection was observed but it did not produce severe injury.
View full abstract
-
Jun Hasegawa, Ken Ikeda, Tai Matsuzawa
1958 Volume 6 Issue 1 Pages
36-42
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
The degradative reaction of phenobarbital was investigated over a pH range of 6.0 to 10.5 from the standpoint of chemical kinetics and the following results were obtained. 1) The degradation is an apparent unimolecular reaction at any fixed pH value and is in itself a bimoleculer reaction catalyzed by hydroxyl ion. The presence of any catalysis besides that by hydroxyl ion is not recognized. The relation between log k and pH is given in Fig. 4. 2) The results obtained well agreed with Eq. (8) which is derived from the postulation described in the theoretical consideration. As seen in Table III, the velocity constant k
1 (molecular form) is larger than k
2 (ionized form), but the decomposition depends on the concentration of hydroxyl ion, and hydrolysis in an alkaline region is very much accelerated. 3) The velocity constant k
2 was slightly smaller than that calculated and further investigation may be necessary for the elucidation of this reason.
View full abstract
-
Shoji Shibata, Mikio Yamazaki
1958 Volume 6 Issue 1 Pages
42-45
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
The aerial part of Fagopyrum cymosum MEISN. was hydroponically cultivated for 6 days in the Houghland solution added with radioactive
14CH
3COONa. Rutin isolated from the leaves was degraded into phloroglucinol and catechol portions, and the specific activity of the degradation fragments was determined. The result indicated that the acetate was directly and dominantly incorporated into phloroglucinol ring in the rutin molecule and an evidence for the head-to-tail linkage of acetate in the biosynthesis of phloroglucinol was provided. The catechol ring of rutin was suggested to be derived indirectly by a different route of biosynthesis.
View full abstract
-
Torizo Takahashi, Fumino Yoneda
1958 Volume 6 Issue 1 Pages
46-49
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
3-Bromo-4-(o-hydroxyphenylamino)-5-nitropyridine prepared from the potassium salt of o-aminophenol and 3-bromo-4-chloro-5-nitropyridine easily yielded 4-nitro-5H-benzo [b] pyrido [4, 3-e]-1, 4-oxazine by the intramolecular condensation in the presence of piperidine or potassium hydroxide. Attempts to prepare a ring-fused azaphenoxazine from the potassium salts of o-aminophenol and 2-chloro-3, 5-dinitropyridine in alkaline medium ended in failure, only giving 2-(o-hydroxyphenylamino)-3, 5-dinitropyridine. On the other hand, when 2-chloro-3, 5-dinitropyridine was allowed to react with o-methylaminophenol, 3-nitro-10-methylbenzo [e] pyrido [3, 2-b]-1, 4-oxazine was obtained. These facts are well explainable from the hypothesis of a chelate ring formation forwarded by Brady. 3-Amino-5-chloro-2-pyridone was condensed with s-trinitroanisole giving 3-chloro-6, 8-dinitro-5H-benzo [b] pyrido [3, 2-e]-1, 4-oxazine.
View full abstract
-
Goro Chihara, Sachiko Yamamoto, Haruo Kameda
1958 Volume 6 Issue 1 Pages
50-54
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
1) A rapid qualitative and semi-quantitative analytical procedure for gall stones by infrared absorption spectra was established, and bands for the chief components of the gall stone, cholesterol, bilirubin calcium, and calcium carbonate were clarified. 2) The component of the gall stone, formed artificially in a rabbit by the injection of serum, was found to be a protein and such a gall stone was found in a few cases of human specimen. 3) The calcium carbonate found in gall stones came in two types, argonite and calcite. 4) This procedure was found to be advantageous when employed in a clinical laboratory.
View full abstract
-
Hisakichi Matsumura, Sadao Iguchi, Magobei Yamamoto, Shigeru Goto
1958 Volume 6 Issue 1 Pages
55-58
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
In the colloidal system of aluminum stearate-peanut oil, deterioration of oil by rancidification brought about undesirable effects, causing the flow rate to increase and rigidity to lower in the region of small shearing stress.
View full abstract
-
Kiyoshi Futaki, Senji Tosa
1958 Volume 6 Issue 1 Pages
58-64
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
Several kinds of 1, 5-substituted s-triazolidino [1, 2-a]-s-triazolidine-3, 7-dithiones and 1, 5-substituted 3, 7-bisalkylthio-s-triazolino [1, 2-a]-s-triazolines (see Tables I and II) were synthesized and their chemical structure was determined from their chemical and spectroscopic properties.
View full abstract
-
Makoto Yokoo
1958 Volume 6 Issue 1 Pages
64-66
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
Some secondary amines were reacted with nitrous acid to produce the corresponding nitrosamines, which were further led to N-amino compounds by reduction with zinc powder and hydrochloric acid and the products were determined quantitatively by Iwasaki's ferricyanide-azotometry, which comprises of oxidizing the amino compounds with potassium ferricyanide to generate nitrogen gas quantitatively. By this method 0.1∼0.2 mole each of dimethylamine, diethylamine, dibenzylamine, diphenylamine, proline, and kainic acid were determined with an accuracy of ±1%.
View full abstract
-
Masayuki Ishikawa
1958 Volume 6 Issue 1 Pages
67-70
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
2'-Oxohexahydrochinin sowie sein Allo-isomer (I bzw. I') wurde durch eine modifizierte Oppenauer-Oxydation mit Lithium-tert-butoxyd als Katalysator und Benzophenon als Oxydant in das 2'-Oxohexahydrochininon (II) ubergefuhrt. Das letztere entsteht auch bei der Kaliumpermanganat-Oxydation von (I) in Aceton-Losung mit sehr schlechter Ausbeute. Der Versuch, den Laktamring in (II) durch Verseifen mit athanolischer Kali-Losung aufzuspalten, fuhrte nicht zum Ziel. Hierbei entstanden 2'-Oxychininon (III) und ein stereoisomeres 2'-Oxychinin (IV) als schwach basischer Teil und 2'-Oxychinin-saure und 3-Athylchinuclidin-6-carbonsaure (hochstwahrscheinlich) als der saurige Teil. Die sterische Beziehung von (II), (III) und (IV) wurde diskutiert.
View full abstract
-
Masayuki Ishikawa
1958 Volume 6 Issue 1 Pages
71-76
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
Die durch Verseifen von 2'-Oxohexahydrochinin (I) bzw. seinem Alloisomer (I') erhaltene Aminosaure (III bzw. II') wurde der modifizierten Oppenauer-Oxydation mittels Lithium-tert-butoxyd und Benzophenon unterworfen. Die hierbei aus der 9-Hydroxylgruppe entstandene Carbonylgruppe kondensiert sich mit der primaren Arylaminogruppe zur entsprechenden Indolcarbonsaure. Der Athylester (XIV) der letzteren gab bei der Reduktion mit LiAlH
4 5'-Methoxydihydrocinchonamin (XV). Uber analoge Reaktionen mit dem Tosylderivat von (III) bzw. (III') wurden beschrieben.
View full abstract
-
Hirotaka Otomasu
1958 Volume 6 Issue 1 Pages
77-81
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
The nitration product of phenazine, which was previously described as 1, 3-dinitrophenazine, was proved to be a mixture of 1, 6-and 1, 9-dinitrophenazines. These structures were determined by their conversion into dihydroxyphenazines by way of diaminophenazines. From the nitration of phenazine N-oxide under high temperature, two isomers, 1, 7-dinitrophenazine 5-oxide and 3, 7-dinitrophenazine-5-oxide were obtained.
View full abstract
-
Takeo Tsukamoto, Tetsuya Komori, Nadao Kinoshita, Naoki Toida, Hirosi ...
1958 Volume 6 Issue 1 Pages
81-87
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
The physical properties of scotopsin, the amino acid component of the substance, and various properties of scotopsin and rhodopsin shown on their titration curves were examined with the object of getting at the clue to clarifying the first process of visual excitement.
View full abstract
-
Hisao Tsukamoto, Hidetoshi Yoshimura, Satoshi Toki
1958 Volume 6 Issue 1 Pages
88-91
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
Method of simultaneous determination of three main metabolites of MHB in urine by paper chromatography in conjunction with ultraviolet spectrophotometry was described. Approximately 25.7% of MHB administered was converted to 3-keto-nor-MHB (4.9%), 3-keto-MHB (4.5%), and 3-OH-MHB (16.3%), and excreted in amounts independent of the dosage administered.
View full abstract
-
Yosoji Ito, Susumu Tsurufuji, Eiichi (the Late) Murai, Sadahiko Ishiba ...
1958 Volume 6 Issue 1 Pages
92-93
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
Effect of tricarballylate, citraconate, tartrate, lactate, and citrate, which are able to form chelating complex with strontium, on the distribution of parenterally administered radioactive strontium was examined, and it was indicated that all of these organic acids markedly decreased skeletal depostion of radiostrontium and four acids other than citrate markedly increased radiostrontium in the blood serum and soft tissues.
View full abstract
-
Shinsaku Natori
1958 Volume 6 Issue 1 Pages
94-97
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
Influence of some agents, such as Tween 80 and serum albumin, on the antibacterial activity of eight compounds including dibenzofuran derivatives was examined. Interaction between antibacterial agents and Tween 80 or serum albumin was also examined by solubility and equilibrium dialysis, and some discussions were made on the cause of decrease of antibacterial action by the addition of surface active agents or serum albumin.
View full abstract
-
Torizo Takahashi, Ken Kanematsu
1958 Volume 6 Issue 1 Pages
98-100
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
The decomposition of bis [(N-4-antipyrinyl-N-methyl) amino] methane (II) with paraformaldehyde and potassium cyanide was effected by heating in glacial acetic acid, and afforded (N-4-antipyrinyl-N-methyl) aminoacetonitrile (VI) and 4-methylaminoantipyrine (I). The condensation of 4-methylaminoantipyrine (I) with paraformaldehyde and potassium cyanide on being warmed in glacial acetic acid also furnished (VI). The respective action of an excess of paraformaldehyde on (I) and (III) in dil. hydrochloric acid gave (II). However, in conc. hydrochloric acid, the respective action of an excess of paraformaldehyde on (I), (II), (III), and (VII) afforded (IV).
View full abstract
-
Kyosuke Tsuda, Saburo Akagi, Yukichi Kishida
1958 Volume 6 Issue 1 Pages
101-104
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
The sterol isolated from Rhodoglossum pulcherum was identified as cholesterol by mixed melting point of various derivatives with the corresponding derivatives prepared from authentic specimen of cholesterol. Furthermore, the identity was confirmed by X-ray diffraction analyses of the algal stenone and cholestenone. The authors also confirmed the existence of cholesterol in several red seaweed listed in Table I. Besides cholesterol, the authors isolated another sterol, chalinasterol from some algae. The discovery of cholesterol might be of some interest to biogenetic study of sterol, because cholesterol has been considered to exist only in animal sources.
View full abstract
-
Hideo Kano, Yasuo Makisumi, Kazuko Ogata
1958 Volume 6 Issue 1 Pages
105-107
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
4-Ethoxycarbonyl-(III) and 4-cyano-5-aminoisoxazole (IV) were prepared by reacting hydroxylamine and ethyl α-ethoxymethylenecyanoacetate (I) or α-ethoxymethylenemalononitrile (II), respectively. These 5-aminoisoxazoles were very unstable toward bases compared with a compound (XI) substituted in 3-position and the ring cleavage occurred at the nitrogen-oxygen bond with subsequent isomerisation to their corresponding nitriles, (V) and (VIII).
View full abstract
-
Eiichi Fujita, Toshiaki Tomimatsu
1958 Volume 6 Issue 1 Pages
107-108
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
From the part of the stem and leaves of Thalictrum Thunbergii DC., magnoflorine was isolated.
View full abstract
-
Y. Kase, T. Yuizono, H. Serikawa, S. Yamamoto, T. Yamasaki, T. Fushimi ...
1958 Volume 6 Issue 1 Pages
109-111
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
I. Pharmacology 1) Antitussive effect : The comparison of antitussive effect of Win-1161-3 with other control drugs is shown in Table I. the 2nd Internal Clinic of this University. The classification of patients was pulmonary tuberculosis with cavity, bronchitis, and bronchial asthma. Average daily dose of the drug administered orally was 1∼2mg. for the children and 4∼6mg. for adults. The classification of the effect was as follows : For pulmonary tuberculosis (17 patients), remarkably effective (5/17), effective (12/17). ineffective (0/17) ; for bronchial asthma and bronchitis (20 patients), remarkably effective (16/20), effective (1/20), ineffective (3/20). It seemed that 6 mg. is sufficient to maintain the effect for a day for adults. The antitussive effect of the drug (3∼4mg.) was compared with those of Dextromethorphan (40 mg.) and codeine (60 mg.) in 17 tuberculosis patients. The effect was the most marked with Win-1161-3, followed by Dextromethorphan and codeine. No side-effect (especially tolerance and cumulation) was observed in 4 tuberculosis patients who were given 6 mg. daily dose of the drug for 40∼50 days. This investigation was supported by Grant in Aid for Development Scientific Research provided by the Ministry of Education (1956).
View full abstract
-
Shigehiko Sugasawa, Seiichi Takano
1958 Volume 6 Issue 1 Pages
111-112
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
-
Toru Masuda, Toyokazu Kishi, Mitsuko Asai
1958 Volume 6 Issue 1 Pages
113-114
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
-
Goro Chihara
1958 Volume 6 Issue 1 Pages
114
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS
-
Yosoji Ito, Susumu Tsurufuji, Mikio Shikita, Sadahiko Ishibashi
1958 Volume 6 Issue 1 Pages
115-116
Published: February 20, 1958
Released on J-STAGE: March 31, 2008
JOURNAL
FREE ACCESS