抄録
De novo lipogenesis appeared to be an important concept of development from fetus and neonate through childhood obesity. Our study of lipoprotein analysis regarding to 'de novo lipogenesis' in fetus and neonate, which indicated the association with pulmonary surfactant synthesis, central nervous system constituents and subcutaneous fat accumulation. These events were happened to begin for the preparation of adaptation mechanism to extra-uterine life from late gestation. Especially it was found that VLDL-TG levels in cord blood revealed drastically increasing over than 32 gestational week, which may be contained the fatty acid derived from de novo lipogenesis and maternal circulation via placenta. However low birth weight infants often observed that excessive subcutaneous fat accumulation was produced by acceleration of stearoyl-CoA desaturase(SCD) activity because of catch up in infancy but which sometimes leading to obesity in later life, and then also observed the relationship between abdominal obesity and the acceleration of SCD activity in adolescence. In our study series, it was suggested that lipogenesis may play an important role for health and disease during fetus to adolescence, so we need to further study nutritional aspects of fatty acid for prevention of life-style related diseases early in life. And from the point of view to resolve the mechanism of epigenetic mechanism in low birth weight, it was considered that fatty acid nutritional treatment in infancy might be one of the important contributions for controlling impaired lipogenesis, especially for repressing the activity of SCD.
