In recent years, demands for Advanced Driving Assistance Systems (ADAS) is increasing, and pedestrian detection has become one of the most important and popular technologies in this system. In the case of pedestrian detection using an in-vehicle camera, since the road environment varies widely according to difference in lightning, weather, etc., it is very difficult to handle them with a single classifier, and numerous false positives are detected. To overcome this problem, this paper proposes a novel pedestrian detection method by scene adaptation based on false positive mining. When we observe the appearance of false positives in in-vehicle camera images, those with similar features are found even in different road environments. The proposed method focuses on the appearance of the detected false positives, and considers it as a scene that the classifier is not good at. By analyzing such a false positive tendency in each scene, the proposed method associates the false positive tendency to each scene and then associates them to each training image. Then, classifiers are constructed so that they can cope with false positives observed in each scene. To evaluate the effectiveness of the proposed method, experiments were conducted on the Caltech Pedestrian Detection Benchmark datasets. Its results showed that the proposed method outperforms the method without adaptation.