Aldose Reductase and Advanced Glycation Endproducts Inhibitory Effect of Phyllostachys nigra

Sang Hoon Jung; Jung Min Lee; Hee Ju Lee; Chul Young Kim; Eun Ha Lee; Byung Hun Um

doi:10.1248/bpb.30.1569

Notes

Aldose Reductase and Advanced Glycation Endproducts Inhibitory Effect of Phyllostachys nigra

Sang Hoon Jung, Jung Min Lee, Hee Ju Lee, Chul Young Kim, Eun Ha Lee, Byung Hun Um

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Keywords: aldose reductase, advanced glycation endproduct, Phyllostachys nigra, luteolin 6-C-(6″-O-trans-caffeoylglucoside), antioxidant, diabetic complications

JOURNAL FREE ACCESS

2007 Volume 30 Issue 8 Pages 1569-1572

DOI https://doi.org/10.1248/bpb.30.1569

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Abstract

To evaluate active principles for diabetic complications from the black bamboo leaves, Phyllostachys nigra, eight compounds were isolated and tested for their effects on rat lens aldose reductase and advanced glycation endproducts. As a result, luteolin 6-C-(6″-O-trans-caffeoylglucoside) was found to show a strong aldose reductase and advanced glycation endproducts inhibition. This compound showed antioxidative activity measured in Photochem^® apparatus. It is concluded, therefore, that luteolin 6-C-(6″-O-trans-caffeoylglucoside) (6), a flavone of this plant, have antioxidative as well as aldose reductase and advanced glycation endproducts inhibitory effects. As a result, this compound could be offered as a leading compound for further study as a new natural products drug for diabetic complications.

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