Apolipoprotein A-I/C-III/A-IV SstI and Apolipoprotein B XbaI Polymorphisms Do not Affect Early Functional and Structural Changes in Atherosclerosis The Cardiovascular Risk in Young Finns Study

Tuomo Nieminen; Mika Kähönen; Md. Shaheenul Islam; Olli T. Raitakari; Nina Hutri-Kähönen; Jukka Marniemi; Markus Juonala; Riikka Rontu; Jorma Viikari; Terho Lehtimäki

doi:10.1253/circj.71.741

Clinical Investigation

Apolipoprotein A-I/C-III/A-IV SstI and Apolipoprotein B XbaI Polymorphisms Do not Affect Early Functional and Structural Changes in Atherosclerosis

The Cardiovascular Risk in Young Finns Study

Tuomo Nieminen, Mika Kähönen, Md. Shaheenul Islam, Olli T. Raitakari, Nina Hutri-Kähönen, Jukka Marniemi, Markus Juonala, Riikka Rontu, Jorma Viikari, Terho Lehtimäki

Author information

Tuomo Nieminen
Department of Pharmacological Sciences, Medical School, University of Tampere
Mika Kähönen
Department of Clinical Physiology, Tampere University Hospital and Medical School
Md. Shaheenul Islam
Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital, and Centre for Laboratory Medicine, Medical School, University of Tampere
The George Institute for International Health
Olli T. Raitakari
Department of Clinical Physiology, University of Turku
Nina Hutri-Kähönen
Department of Paediatrics, Tampere University Hospital
Jukka Marniemi
Department of Health and Functional Capacity, National Public Health Institute
Markus Juonala
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
Riikka Rontu
Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital, and Centre for Laboratory Medicine, Medical School, University of Tampere
Jorma Viikari
Department of Medicine, Turku University Hospital and University of Turku
Terho Lehtimäki
Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital, and Centre for Laboratory Medicine, Medical School, University of Tampere

Keywords: Apolipoprotein, Arterial compliance, Carotid artery, Flow-mediated vasodilatation, Media - intima thickness, Polymorphism

JOURNAL FREE ACCESS

2007 Volume 71 Issue 5 Pages 741-745

DOI https://doi.org/10.1253/circj.71.741

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Abstract

Background The present study was designed to investigate the effects of apoB XbaI and apoA-I/C-III/A-IV SstI polymorphisms to carotid artery intima - media thickness (IMT), carotid artery compliance (CAC) and brachial artery flow-mediated vasodilatation (FMD). Methods and Results As part of the Cardiovascular Risk in Young Finns Study, the carotid IMT, CAC and brachial FMD of 2,265 subjects (mean age ± SD 32 ±5 years) were measured with ultrasonography, and genotyping of the apolipoprotein polymorphisms was performed. The frequencies of the genotypes did not differ between the groups with high (above median 0.57 mm) and low (below median) IMT, CAC or FMD. The average carotid IMT differed between the 3 apoB XbaI genotypes (ANOVA, p=0.04), but not between the apoA-I/C-III/A-IV SstI genotypes (ANOVA, p=0.53). The relationship between the polymorphisms and carotid IMT was not significant in any of the covariate-adjusted logistic and linear regression analyses. CAC and FMD were not influenced by either of the polymorphisms in ANOVA and regression analyses. Conclusions The polymorphisms apoA-I/C-III/A-IV SstI and apoB XbaI do not seem to affect carotid artery characteristics or brachial artery FMD in young adulthood. (Circ J 2007; 71: 741 - 745)

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