This study evaluated how zirconia thickness affects shear bond strength (SBS) between zirconia and dual-cure resin cement. Eighty specimens (40 blocks of 1 mm thickness zirconia and 20 of each 1.5 and 2 mm) were divided into 8 groups according to zirconia thickness and light-curing time. Group A, B, C, and D were light-polymerized during 20 s and group E, F, G, and H were light-cured during 40 s. Self-adhesive dual-cure resin cement was placed onto the zirconia surfaces and then light-polymerized. The mean SBS of the 40 s curing time group was statistically higher than that of the 20 s curing time group. However, curing time did not affect the SBS significantly in the 2 mm thickness groups. The mean SBS of the 1.5 and 2 mm groups were statistically lower than those 1 mm groups. Therefore, zirconia thickness significantly affected the SBS of self-adhesive dual-cure resin cement.