貼付剤の粘着特性とその評価法

抄録

Transdermal patches are one of pharmaceutical dosage forms, and their adhesive properties such as ease of administration and difficulty in peeling off during medication tend to affect patients’ adherence to treatment. Depending on the stickiness of the products, some patients prefer to use brand-name drugs rather than generic drugs, and vice versa. Transdermal patches are a type of adhesive products, but have some aspects that are different from industrial tapes: First, they must be harmless to human body. For this reason, the adhesives that can be used are very limited. Second, many of them are small in size. Since quality tests are performed using the final product, the adhesion test methods applicable to small transdermal patches are limited. This article introduces the types of patches, the excipients used in adhesives, the adhesive properties of formulations, and how to evaluate the properties, while briefly explaining the pharmaceutical- specific conditions and regulations.