Distributions of Steroid 5α-Reductase and 17α-Hydroxylase/C17,20-lyase (P450c17) Immunoreactivities in Rat Gastric Mucosa

抄録

We examined the immunohistochemical localization of steroid 5α-reductase type 1 and 17α-hydroxylase/C17,20-lyase (P450c17) in rat gastric mucosa. Immunoreactivity of 5α-reductase was localized in the chief cells and the mucous neck cells. P450c17 immunoreactivity was localized in the parietal cells. Subcellular localizations of both 5α-reductase and P450c17 were on the membrane of endoplasmic reticulum. P450c17 is a key enzyme of androgen biosynthesis, and 5α-reductase has a high affinity for testosterone and catalyzes the conversion of testosterone to its 5α-reduced metabolite. Thus, it is suggested that there is an androgenic metabolic pathway in rat gastric mucosa.