Abstract
Changes in the distribution of radioactive carbon from [U-14C] glucose in mice with carbon monoxide were studied by whole-body autoradiography.
Two periods could be distinguished in the changes of 14C concentrations in organs affected by CO poisoning with prolonged exposure time up to 6 hrs: the first stage of 30 and 60min and the second stage of over one hr. In the first stage, a marked decrease in 14C concentration was shown for the brain, palatine, submaxillary and Harder's gland, while an increase was shown for the myocardium, liver, kidney cortex and blood. In the second stage, however, changes of 14C concentration in organs were less pronounced and showed for almost all organs a trend rather resembling that of blood.
