EFFECT OF HEMODYNAMIC FACTORS IN RENAL GLOMERULUS

I. ALTERATIONS OF GLOMERULAR BASEMENT MEMBRANE IN THE EXPERIMENTAL CONGESTIVE KIDNEY

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Renal glomerular function cannot be attributed solely to structural elements in the glomerular capillary wall. Such structural elements certainly contribute to barrier function during ultrafiltration, but normal hemodynamic conditions are also required for optimal ultrafiltration. In order to change the normal hemodynamic state of glomerular capillary, an experimental congestive kidney was made by clipping unilateral renal vein in rabbits.
The glomerular basement membrane was observed morphologically and cytochemically (performic acid-phosphotungstic acid reaction, PFP reaction) at various time intervals.
The glomerular basement membrane in the congestive kidney showed a localized or widespread thickening and polypoid changes. Cytochemical findings were similar to that of controls.