DEVELOPMENTAL CHANGE OF THE IMMUNOREACTIVITY TO ANTI-CALMODULIN ANTIBODY IN THE MOUSE BRAIN
1984 年 17 巻 2 号 p. 109-117
詳細
1984 年 17 巻 2 号 p. 109-117
Calmodulin is a small, acidic calcium-binding protein concentrated in the nervous system. The immunohistochemical localization of calmodulin in the developing mouse brain was studied light-microscopically using the specific anti-calmodulin IgG which was elicited in the rabbit with native calmodulin of bovine brain. The immunoreactivity of the cell somata and their processes found in the adult brain did not appear simultaneously but in some sequential order with the regions of the brain. On the other hand, immunoreactivity disappeared during the development. This reaction of disappearance was also abolished by the neutralization of the antibody with calmodulin. From the results of the appearance as well as the disappearance of the immunoreactivity, the pattern of the immunostaining reached that of the adult by 17 days of age.
