抄録
The expression of epidermal growth factor receptor (EGFR) was studied in benign and malignant tumors of the breast using a monoclonal antibody of this receptor. The benign lesions were obtained from mastopathy (14 cases), fibroadenoma (12 cases), and malignant lesions, and from papillo-tubular (17 cases), solid-tubular (15 cases), and scirrhous carcinomas (10 cases). The highest incidence of positive EGFR staining was found in the scirrhous carcinomas (70%). The incidence was moderate in tubular carcinomas (60-65%), and low in solid or papillary type (13-35%). Immunolocalization of EGFR staining was divided into 1) luminal-border positive type, 2) cell-membrane positive type, and 3) cytoplasm positive type. In benign lesions, EGFR expression was usually of the luminal border or cell membrane positive type. A heterogeneity of EGFR staining was found in malignant tumors, but evidence suggests in scirrhous carcinoma that EGFR expression is positively correlated with tumor cell proliferation.
