Nuclear Localization of P70-Like Protein in Neurons of the Superior Colliculus and Substantia Nigra of the Gerbil

抄録

P70, a 70kDa protein found in the cobalt-induced epileptogenic cortex of the rat brain, has been implicated in epileptogenesis. In the gerbil brain, we found that an antibody directed against rat P70 reacts with a similar protein which is localized mainly in the nucleus and Golgi apparatus of the neurons of the superior colliculus and substantia nigra. Surprisingly, similar immunoreactivity is seen in young pups which have not yet experienced motor seizures, and in animals from seizure-resistant group, indicating that this protein may have a role other than direct participation in epileptogenesis as assumed to be the case for rat P70.