Relationships between Cerebro Vascular Disease(CVD) mortality and monthly mean outdoor temperature were analyzed to obtain some information for the thermal environment design, in 7 regions in Japan. CVD mortality was observed to be minimum at ca. 22℃, the monthly mean outdoor temperature, in Hokkaido, at ca. 25℃ in Kyoto city, Tokyo, Ishikawa, Wakayama prefectures and at ca. 28℃ in Okinawa prefecture. This mortality-minimum outdoor temperature varied according to each average air temperature. It was considered as the thermal neutral point for human and discussed in connection with the goal of thermal environment design to secure safety before comfort.