The fatigue resistance of sealed joint to relative story displacement movement was studied experimentally and analytically, and the new joint design method providing the performance of sealed joint was proposed by considering its service life. At a first step, the three items required to make the joint design method were investigated, namely, the effect of cross sectional size and shape of sealed joint, the fatigue resistance of sealant at inter-section zones of sealed joints to slide motion and rocking motion of curtain wall panels and the effect of curvature radii at the comer of panels to improve the fatigue resistance of inter-sections of sealed joints. Then, the process of a new joint design method at the linear section and the intersection of sealed joint to relative story displacement movement were made on the basis of the experimental data. We further more proposed the methodology to judge the expected service life of sealed joint.