Two types of hydro-fluorocarbons (HFC245fa and HFC365mfc) which are the substitutes for HCFC 141b has been put in practical use as new blowing agents for polyurethane spray insulation foam jsut since 2004. In this study, we developed estimation method for aging of thermal conductivity in HFC-blown spray foam with whole skin based on experiments. Furthermore, we simulate change of heat load by heating/cooling caused by the aging with house model.