A computer program for assisting of seismic isolators layout-planning was developed. Isolator data base which include dimensional characteristics and performance such as stiffness and damping ratio, was prepared in the program. Once the design conditions, such as soil condition, characteristics of super structures, coordinates and load of columns are given, the isolators are automatically selected from the data base and the seismic response is computed by both response spectrum analysis and time-history analysis. Furthermore, the optimization of the isolator size is conducted according to genetic algorithm. In this paper, the feature of the program including genetic algorithm function was introduced.