Glutathione Peroxidase-Like Catalytic Activities of Ion-Exchange Resins Modified with Metalloporphyrins

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Some of the ion-exchange resins modified with metalloporphyrins have been found to exhibit glutathione-peroxidase (GSHPx)-like catalytic activities for hydrogen peroxide and cumene hydroperoxide in the oxidative reaction of glutathione to disulfide. In particular, the anion-exchange resin modified with Mn(III)-tetrakis(sulfophenyl)porphine (Mn-TSPP_r) exhibited stronger activity than GSHPx, and hence Mn-TSPP_r was expected to be a good mimesis in place of GSHPx or immobilized GSHPx for the determination of peroxide.