Imaging Mass Spectrometry Reveals a Decrease of Cardiolipin in the Kidney of NASH Model Mice

Takahiro HAYASAKA; Hirotoshi FUDA; Shu-Ping HUI; Hitoshi CHIBA

doi:10.2116/analsci.32.473

Notes

Imaging Mass Spectrometry Reveals a Decrease of Cardiolipin in the Kidney of NASH Model Mice

Takahiro HAYASAKA, Hirotoshi FUDA, Shu-Ping HUI, Hitoshi CHIBA

著者情報

キーワード: Imaging, matrix-assisted laser desorption/ionization, non-alcoholic steatohepatitis, kidney, cardiolipin

ジャーナルフリー

2016 年 32 巻 4 号 p. 473-476

DOI https://doi.org/10.2116/analsci.32.473

詳細

抄録

Non-alcoholic steatohepatitis (NASH) can be complicated with chronic kidney disease (CKD). In this study, changes in the distribution of biomolecules in the kidney were studied in NASH model mice with the use of imaging mass spectrometry (IMS). The mass spectra and ion images of IMS showed that the signals of cardiolipin (CL) species were decreased in the kidney cortex of the NASH mice. The decrease of CL might therefore suggest the kidney involvement of NASH.

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