Stopped-Flow Kinetic Study on Intermediate of Theophylline Oxidation Reaction via Rapid-Scanning UV/VIS Spectroscopy

抄録

Study on the intermediary species of theophylline oxidation process is very important for understanding its pharmacological action. Theophylline is a drug commonly used in treatment of asthma.In our study, we found that a red intermediate which appeared and then disappeared immediately after we mixed Ce(IV) with theophylline. We have investigated this intermediate via rapid-scanning stopped-flow UV/Visible spectroscopy combined with single wavelength stopped-flow technique. Successive reaction kinetic simulation model has been used to study properties of the intermediate. A possible reaction mechanism is proposed.