STUDIES ON BIOSYNTHESIS OF KASUGAMYCIN. I

BIOSYNTHESIS OF KASUGAMYCIN AND THE KASUGAMINE MOIETY

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Incorporation of U-¹⁴C-glucose, U-¹⁴C-maltose, U-¹⁴C-mannose, U-¹⁴Cribose, 1-¹⁴C-glycerol, U-¹⁴C-pyruvate, 1-¹⁴C-acetate, U-¹⁴C-myomositol, 1-¹⁴C-glycine, 2-¹⁴C-glycine and U-¹⁴C-glycine into kasugamycin and its kasugamine moiety was reported. The incorporation of U-¹⁴C-glucose and U-¹⁴C-mannose into kasugamycin was 5-fold that of U-¹⁴C-maltose. U-¹⁴C-glucose, U-¹⁴C-mannose and U-¹⁴C-maltose were incorporated into the kasugamine moiety more than into the other moieties. U-¹⁴C-Myoinositol, 1-¹⁴C-glycine and 2-¹⁴C-glycine were incorporated into kasugamycin mostly in the parts other than kasugamine.