抄録
Enduracidin showed antibacterial activity in vitro against Gram-positive bacteria and N. GONORRHOEAE, but not against Gram-negative bacteria. The antibacterial activity of enduracidin was not greatly influenced by the pH of the test medium. Enduracidin was more stable at pH 4 and 7 than at pH 9. This antibiotic demonstrated bactericidal as well as bacteriostatic activity in vitro at a similar concentration against Staph. aureus. The development of resistance to enduracidin was slow and no cross resistance was observed between enduracidin and other known antibiotics. Enduracidin was effective against experimental infections produced in mice by strains of Staph. aureus, Sterept. Pyogenes and D. pneumoniae type I. Enduracidin was most effective against streptococcal infection. This antibiotic was effective by the subcutaneous, intraperitoneal and intravenous routes, but not orally. A single intramuscular dose of 2 mg/kg of enduracidin in the rabbit produced significant plasma levels extending even to 24 hours.
