MACROLIDE ANTIBIOTICS M-4365 PRODUCED BY MICROMONOSPORA III. <i>IN VITRO</i> ANTIMICROBIAL ACTIVITY OF ANTIBIOTIC M-4365G<sub>2</sub> (DE-EPOXY ROSAMICIN)

TOUTARO YAMAGUCHI; HARUO HAYASAKA; HIROTSUGU YOSHIDA; TADAHIRO MATSUSHITA; AKEMI YAMABE; SATOSHI OHSHIMA

doi:10.7164/antibiotics.31.433

MACROLIDE ANTIBIOTICS M-4365 PRODUCED BY MICROMONOSPORA

III. IN VITRO ANTIMICROBIAL ACTIVITY OF ANTIBIOTIC M-4365G₂ (DE-EPOXY ROSAMICIN)

TOUTARO YAMAGUCHI, HARUO HAYASAKA, HIROTSUGU YOSHIDA, TADAHIRO MATSUSHITA, AKEMI YAMABE, SATOSHI OHSHIMA

著者情報

ジャーナルフリー

1978 年 31 巻 5 号 p. 433-440

DOI https://doi.org/10.7164/antibiotics.31.433

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抄録

Antibiotic M-4365G₂ (de-epoxy rosamicin) produced by Micromonospora capillata MCRL 0940 is a new basic 16-membered macrolide antibiotic with activity equal to or superior to erythromycin and josamycin against Gram-positive bacteria. Of interest are the high degree of activity against Gram-negative bacilli and mycoplasmas, and striking inhibitory effects against indole-producing Proteus spp. Bactericidal activity of M-4365G₂ is also to be noticed.

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