SYNTHESIS AND IN VITRO ACTIVITY OF A NEW CARBAPENEM, RS-533

TETSUO MIYADERA; YUKIO SUGIMURA; TOSHIHIKO HASHIMOTO; TERUO TANAKA; KIMIO IINO; TOMOYUKI SHIBATA; SHINICHI SUGAWARA

doi:10.7164/antibiotics.36.1034

SYNTHESIS AND IN VITRO ACTIVITY OF A NEW CARBAPENEM, RS-533

TETSUO MIYADERA, YUKIO SUGIMURA, TOSHIHIKO HASHIMOTO, TERUO TANAKA, KIMIO IINO, TOMOYUKI SHIBATA, SHINICHI SUGAWARA

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JOURNAL FREE ACCESS

1983 Volume 36 Issue 8 Pages 1034-1039

DOI https://doi.org/10.7164/antibiotics.36.1034

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Abstract

The synthesis and in vitro antimicrobial activity of a new synthetic carbapenem, (5R, 6S)-6-[(R)-1-hydroxyethyl]-2-[(S)-l-acetimidoylpyrrolidin-3-ylthio]-l-carbapen-2-em-3-carboxylic acid (RS-533), are described. The MIC values of related penems and carbapenems are also given for comparison with those of the new carbapenem.

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